Estimation of outer hair cells function in chronic bilateral tinnitus patients with normal hearing using distortion product otoacoustic emissions
,
Abstract
Background and Aim: It is not clear if the measurement of distortion product otoacoustic emissions (DPOAE) at frequencies above 8 kHz adds any value in determining the differences in the cochlear function between patients with and without tinnitus. This study aimed to compare DPOAE in the frequency range of 0.5−10 kHz in patients with normal hearing with and without tinnitus.
Methods: This comparative cross-sectional study was conducted on 20 individuals with tinnitus and normal hearing as a study group (SG) and a control group (CG) of 20 normal-hearing individuals without tinnitus. The DPOAE was measured with F1/F2 = 1.22 and intensities of F1 = 65 dB SPL and F2 =55 dB SPL in the frequency range of 0.5−10 kHz, moreover in the frequency of tinnitus in SG and corresponding frequency in CG.
Results: DPOAE level at 10 kHz did not differ significantly between SG and CG (p = 0.491). However, the mean of overall DPOAE level, DPOAE level at the frequency of tinnitus, and F2 values of 2.5, 5, and 6.298 kHz were significantly lower in SG than CG (p < 0.05).
Conclusion: Measurement of DPOAE at 10 kHz did not seem to add any value in determining the differences in the cochlear function between patients with and without tinnitus. However, decreased DPOAE levels at 2.5, 5, and 6.298 kHz which were observed among patients who have tinnitus and normal hearing, indicates some outer hair cells damage that was not detectable by conventional audiometry.
1. Sanchez TG, Medeiros ÍR, Levy CP, Ramalho JD, Bento RF. Tinnitus in normally hearing patients: clinical aspects and repercussions. Braz J Otorhinolaryngol. 2005;71(4):427-31. doi: 10.1016/s1808-8694(15)31194-0
2. Chari DA, Limb CJ. Tinnitus. Med Clin North Am. 2018;102(6):1081-93. doi: 10.1016/j.mcna.2018.06.014
3. Weisz N, Hartmann T, Dohrmann K, Schlee W, Norena A. High-frequency tinnitus without hearing loss does not mean absence of deafferentation. Hear Res. 2006;222(1-2):108-14. doi: 10.1016/j.heares.2006.09.003
4. Salvi RJ, Ding D, Wang J, Jiang WH. A review of the effects of selective inner hair cell lesions on distortion product otoacoustic emissions, cochlear function and auditory evoked potentials. Noise Health. 2000;2(6):9-25.
5. Xiong B, Liu Z, Liu Q, Peng Y, Wu H, Lin Y, et al. Missed hearing loss in tinnitus patients with normal audiograms. Hear Res. 2019;384:107826. doi: 10.1016/j.heares.2019.107826
6. Bohne B CW. Growth of hearing loss and cochlear lesion with increasing duration of noise exposure. In: Hamernik RP, Henderson D, Salvi RJ, editors. New perspectives on noise-induced hearing loss. New York: Raven Press. 1982. p. 283-302.
7. Kemp DT. Otoacoustic emissions in perspective, In: Robinette MS, Glattke TJ, editors. Otoacoustic emissions: clinical applications. 1st ed. New York, NY: Thieme; 1997. p. 1-21.
8. Shiomi Y, Tsuji J, Naito Y, Fujiki N, Yamamoto N. Characteristics of DPOAE audiogram in tinnitus patients. Hear Res. 1997;108(1-2):83-8. doi: 10.1016/s0378-5955(97)00043-9
9. Jastreboff PJ, Hazell JW. A neurophysiological approach to tinnitus: clinical implications. Br J Audiol. 1993;27(1):7-17. doi: 10.3109/03005369309077884
10. Gorga MP, Neely ST, Bergman BM, Beauchaine KL, Kaminski JR, Peters J, et al. A comparison of transient-evoked and distortion product otoacoustic emissions in normal-hearing and hearing-impaired subjects. J Acoust Soc Am. 1993;94(5):2639-48. doi: 10.1121/1.407348
11. Dadoo S, Sharma R, Sharma V. Oto-acoustic emissions and brainstem evoked response audiometry in patients of tinnitus with normal hearing. Int Tinnitus J. 2019;23(1):17-25. doi: 10.5935/0946-5448.20190004
12. Granjeiro RC, Kehrle HM, Bezerra RL, Almeida VF, Sampaio ALL, Oliveira CA. Transient and distortion product evoked oto-acoustic emissions in normal hearing patients with and without tinnitus. Otolaryngol Head Neck Surg. 2008;138(4):502-6. doi: 10.1016/j.otohns.2007.11.012
13. Castello E. Distortion products in normal hearing pati¬ents with tinnitus. Boll Soc Ital Biol Sper. 1997;73(5-6):93-100.
14. Onishi ET, Fukuda Y, Suzuki FA. Distortion product otoacoustic emissions in tinnitus patients. Int Tinnitus J. 2004;10(1):13-6.
15. Bartnik G, Rogowski M, Fabijanska A, Raj-Koziak D, Borawska B. [Analysis of the distortion product otoacoustic emission (DPOAE) and input/output function (I/O) in tinnitus patient with normal hearing]. Otolaryngol Pol. 2004;58(6):1127-32. Polish
16. Ami M, Abdullah A, Awang MA, Liyab B, Saim L. Relation of distortion product otoacoustic emission with tinnitus. Laryngoscope. 2008;118(4):712-7. doi: 10.1097/MLG.0b013e318161e521
17. Emadi M, Rezaei M, Najafi S, Faramarzi A, Farahani F. Comparison of the Transient Evoked Otoacoustic Emissions (TEOAEs) and Distortion Products Otoacoustic Emissions (DPOAEs) in Normal Hearing Subjects With and Without Tinnitus. Indian J Otolaryngol Head Neck Surg. 2018;70(1):115-8. doi: 10.1007/s12070-015-0824-9
18. Mokrian H, Shaibanizadeh A, Farahani S, Jalaie S, Mahdi P, Amali A, et al. Evaluation of distortion and transient evoked otoacoustic emission in tinnitus patients with normal hearing. Iran J Otorhinolaryngol. 2014;26(1):19-24. doi: 10.22038/IJORL.2014.1889
19. Hoffman HJ, Dobie RA, Losonczy KG, Themann CL, Flamme GA. Declining prevalence of hearing loss in US adults aged 20 to 69 years. JAMA Otolaryngol Head Neck Surg. 2017;143(3):274-85. doi: 10.1001/jamaoto.2016.3527
20. Hughson W, Westlake H. Manual for program outline for rehabilitation of aural casualties both military and civilian. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1944;48(Suppl.):1-15.
21. Vernon JA, Meikle MB. Tinnitus masking: unresolved problems. Ciba Found Symp. 1981;85:239-62. doi: 10.1002/9780470720677.ch14
22. Ramos JA, Kristensen SGB, Beck DL. An overview of OAEs and normative data for DPOAEs. Hear Rev. 2013;20(11):30-3.
23. Gorga MP, Neely ST, Ohlrich B, Hoover B, Redner J, Peters J. From laboratory to clinic: A large scale study of distortion product otoacoustic emissions in ears with normal hearing and ears with hearing loss. Ear Hear. 1997;18(6):440-55. doi: 10.1097/00003446-199712000-00003
24. Bonfils P, Avan P. Distortion-product otoacoustic emissions: Values for clinical use. Arch Otolaryngol Head Neck Surg. 1992;118(10):1069-76. doi: 10.1001/archotol.1992.01880100061014
25. Sztuka A, Pospiech L, Gawron W, Dudek K. DPOAE in estimation of the function of the cochlea in tinnitus patients with normal hearing. Auris Nasus Larynx. 2010;37(1):55-60. doi: 10.1016/j.anl.2009.05.001
26. Aazh H, Moore BCJ, Lammaing K, Cropley M. Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: Patients' evaluations of the effectiveness of treatments. Int J Audiol. 2016;55(9):514-22. doi: 10.1080/14992027.2016.1178400
27. Gouveris H, Maurer J, Mann W. DPOAE-Grams in Patients with Acute Tonal Tinnitus. Otolaryngol Head Neck Surg. 2005;132(4):550-3. doi: 10.1016/j.otohns.2004.09.031
28. Abo Jamous N, Assaf S, Qasem H. Otoacoustic emissions and tinnitus in normal hearing. Journal of the Royal Medical Services. 2010;17(2):27-31.
2. Chari DA, Limb CJ. Tinnitus. Med Clin North Am. 2018;102(6):1081-93. doi: 10.1016/j.mcna.2018.06.014
3. Weisz N, Hartmann T, Dohrmann K, Schlee W, Norena A. High-frequency tinnitus without hearing loss does not mean absence of deafferentation. Hear Res. 2006;222(1-2):108-14. doi: 10.1016/j.heares.2006.09.003
4. Salvi RJ, Ding D, Wang J, Jiang WH. A review of the effects of selective inner hair cell lesions on distortion product otoacoustic emissions, cochlear function and auditory evoked potentials. Noise Health. 2000;2(6):9-25.
5. Xiong B, Liu Z, Liu Q, Peng Y, Wu H, Lin Y, et al. Missed hearing loss in tinnitus patients with normal audiograms. Hear Res. 2019;384:107826. doi: 10.1016/j.heares.2019.107826
6. Bohne B CW. Growth of hearing loss and cochlear lesion with increasing duration of noise exposure. In: Hamernik RP, Henderson D, Salvi RJ, editors. New perspectives on noise-induced hearing loss. New York: Raven Press. 1982. p. 283-302.
7. Kemp DT. Otoacoustic emissions in perspective, In: Robinette MS, Glattke TJ, editors. Otoacoustic emissions: clinical applications. 1st ed. New York, NY: Thieme; 1997. p. 1-21.
8. Shiomi Y, Tsuji J, Naito Y, Fujiki N, Yamamoto N. Characteristics of DPOAE audiogram in tinnitus patients. Hear Res. 1997;108(1-2):83-8. doi: 10.1016/s0378-5955(97)00043-9
9. Jastreboff PJ, Hazell JW. A neurophysiological approach to tinnitus: clinical implications. Br J Audiol. 1993;27(1):7-17. doi: 10.3109/03005369309077884
10. Gorga MP, Neely ST, Bergman BM, Beauchaine KL, Kaminski JR, Peters J, et al. A comparison of transient-evoked and distortion product otoacoustic emissions in normal-hearing and hearing-impaired subjects. J Acoust Soc Am. 1993;94(5):2639-48. doi: 10.1121/1.407348
11. Dadoo S, Sharma R, Sharma V. Oto-acoustic emissions and brainstem evoked response audiometry in patients of tinnitus with normal hearing. Int Tinnitus J. 2019;23(1):17-25. doi: 10.5935/0946-5448.20190004
12. Granjeiro RC, Kehrle HM, Bezerra RL, Almeida VF, Sampaio ALL, Oliveira CA. Transient and distortion product evoked oto-acoustic emissions in normal hearing patients with and without tinnitus. Otolaryngol Head Neck Surg. 2008;138(4):502-6. doi: 10.1016/j.otohns.2007.11.012
13. Castello E. Distortion products in normal hearing pati¬ents with tinnitus. Boll Soc Ital Biol Sper. 1997;73(5-6):93-100.
14. Onishi ET, Fukuda Y, Suzuki FA. Distortion product otoacoustic emissions in tinnitus patients. Int Tinnitus J. 2004;10(1):13-6.
15. Bartnik G, Rogowski M, Fabijanska A, Raj-Koziak D, Borawska B. [Analysis of the distortion product otoacoustic emission (DPOAE) and input/output function (I/O) in tinnitus patient with normal hearing]. Otolaryngol Pol. 2004;58(6):1127-32. Polish
16. Ami M, Abdullah A, Awang MA, Liyab B, Saim L. Relation of distortion product otoacoustic emission with tinnitus. Laryngoscope. 2008;118(4):712-7. doi: 10.1097/MLG.0b013e318161e521
17. Emadi M, Rezaei M, Najafi S, Faramarzi A, Farahani F. Comparison of the Transient Evoked Otoacoustic Emissions (TEOAEs) and Distortion Products Otoacoustic Emissions (DPOAEs) in Normal Hearing Subjects With and Without Tinnitus. Indian J Otolaryngol Head Neck Surg. 2018;70(1):115-8. doi: 10.1007/s12070-015-0824-9
18. Mokrian H, Shaibanizadeh A, Farahani S, Jalaie S, Mahdi P, Amali A, et al. Evaluation of distortion and transient evoked otoacoustic emission in tinnitus patients with normal hearing. Iran J Otorhinolaryngol. 2014;26(1):19-24. doi: 10.22038/IJORL.2014.1889
19. Hoffman HJ, Dobie RA, Losonczy KG, Themann CL, Flamme GA. Declining prevalence of hearing loss in US adults aged 20 to 69 years. JAMA Otolaryngol Head Neck Surg. 2017;143(3):274-85. doi: 10.1001/jamaoto.2016.3527
20. Hughson W, Westlake H. Manual for program outline for rehabilitation of aural casualties both military and civilian. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1944;48(Suppl.):1-15.
21. Vernon JA, Meikle MB. Tinnitus masking: unresolved problems. Ciba Found Symp. 1981;85:239-62. doi: 10.1002/9780470720677.ch14
22. Ramos JA, Kristensen SGB, Beck DL. An overview of OAEs and normative data for DPOAEs. Hear Rev. 2013;20(11):30-3.
23. Gorga MP, Neely ST, Ohlrich B, Hoover B, Redner J, Peters J. From laboratory to clinic: A large scale study of distortion product otoacoustic emissions in ears with normal hearing and ears with hearing loss. Ear Hear. 1997;18(6):440-55. doi: 10.1097/00003446-199712000-00003
24. Bonfils P, Avan P. Distortion-product otoacoustic emissions: Values for clinical use. Arch Otolaryngol Head Neck Surg. 1992;118(10):1069-76. doi: 10.1001/archotol.1992.01880100061014
25. Sztuka A, Pospiech L, Gawron W, Dudek K. DPOAE in estimation of the function of the cochlea in tinnitus patients with normal hearing. Auris Nasus Larynx. 2010;37(1):55-60. doi: 10.1016/j.anl.2009.05.001
26. Aazh H, Moore BCJ, Lammaing K, Cropley M. Tinnitus and hyperacusis therapy in a UK National Health Service audiology department: Patients' evaluations of the effectiveness of treatments. Int J Audiol. 2016;55(9):514-22. doi: 10.1080/14992027.2016.1178400
27. Gouveris H, Maurer J, Mann W. DPOAE-Grams in Patients with Acute Tonal Tinnitus. Otolaryngol Head Neck Surg. 2005;132(4):550-3. doi: 10.1016/j.otohns.2004.09.031
28. Abo Jamous N, Assaf S, Qasem H. Otoacoustic emissions and tinnitus in normal hearing. Journal of the Royal Medical Services. 2010;17(2):27-31.
| Files | ||
| Issue | Vol 30 No 2 (2021) | |
| Section | Research Article(s) | |
| DOI | https://doi.org/10.18502/avr.v30i2.6094 | |
| Keywords | ||
| Tinnitus normal hearing outer hair cell distortion product otoacoustic emission | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Karimiani A, Rouhbakhsh N, Zamiri Abdollahi F, Jalaie S. Estimation of outer hair cells function in chronic bilateral tinnitus patients with normal hearing using distortion product otoacoustic emissions. Aud Vestib Res. 2021;30(2):102-109.
