Transcranial direct current stimulation in treatment of tinnitus
Abstract
Background and Aim: Approximately 20% of general population is struggling with tinnitus. Recent theories on tinnitus are mainly based on impairments in the central auditory system that can lead to tinnitus. Recent studies have shown that tinnitus is not simply a result of the involvement of one brain region or pathway; but it can be caused by simultaneous involvement of multiple brain regions. Due to lack of information about the tinnitus etiology, site, and pathophysiology, there is still no any specific and common method for its management. In recent years, neuromodulation techniques such as transcranial direct current stimulation (tDCS) has been proposed for management of tinnitus. In this study, we aimed to review the role of tDCS in tinnitus management.
Recent Findings: Based on the inclusion criteria, 7 eligible articles were selected for review. Most of them showed the beneficial effects of tDCS on tinnitus management.
Conclusion: The tDCS can be an effective technique for management of tinnitus. One of the main challenges for using tDCS in tinnitus patients is the differnce in stimulation parameters; therefore, more studies are recommended for obtaining its ideal parameters.
1. Vahdatinia R, Keane J, Troncoso V, Goldstein LB. Tinnitus: diagnosis and treatment options. Heighpubs Otolaryngol Rhinol. 2017;1:053-9. doi: 10.29328/journal.hor.1001010
2. Kim HJ, Lee HJ, An SY, Sim S, Park B, Kim SW, et al. Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS One. 2015;10(5):e0127578. doi: 10.1371/journal.pone.0127578
3. Emadi M, Rezaei M, Najafi S, Faramarzi A, Farahani F. Comparison of the transient evoked otoacoustic emissions (TEOAEs) and distortion products otoacoustic emissions (DPOAEs) in normal hearing subjects with and without tinnitus. Indian J Otolaryngol Head Neck Surg. 2018;70(1):115-8. doi: 10.1007/s12070-015-0824-9
4. Henry JA, Roberts LE, Caspary DM, Theodoroff SM, Salvi RJ. Underlying mechanisms of tinnitus: review and clinical implications. J Am Acad Audiol. 2014;25(1):5-22; quiz 126. doi: 10.3766/jaaa.25.1.2
5. Eggermont JJ. Pathophysiology of tinnitus. Prog Brain Res. 2007;166,19-35. doi: 10.1016/S0079-6123(07)66002-6
6. van der Loo E, Gais S, Congedo M, Vanneste S, Plazier M, Menovsky T, et al. Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex. PLoS One. 2009;4(10):e7396. doi: 10.1371/journal.pone.0007396
7. De Ridder D, Elgoyhen AB, Romo R, Langguth B. Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc Natl Acad Sci U S A. 2011;108(20):8075-80. doi: 10.1073/pnas.1018466108
8. De Ridder D, Vanneste S. EEG driven tDCS versus bifrontal tDCS for tinnitus. Front Psychiatry. 2012;3:84. doi: 10.3389/fpsyt.2012.00084
9. Schlee W, Hartmann T, Langguth B, Weisz N. Abnormal resting-state cortical coupling in chronic tinnitus. BMC Neurosci. 2009;10:11. doi: 10.1186/1471-2202-10-11
10. Langguth B, Goodey R, Azevedo A, Bjorne A, Cacace A, Crocetti A, et al. Consensus for tinnitus patient asse¬ssment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006. Prog Brain Res. 2007;166:525-36. doi: 10.1016/S0079-6123(07)66050-6
11. Dobie RA. Depression and tinnitus. Otolaryngol Clin North Am. 2003;36(2):383-8. doi: 10.1016/s0030-6665(02)00168-8
12. Mühlau M, Rauschecker JP, Oestreicher E, Gaser C, Röttinger M, Wohlschläger AM, et al. Cereb Cortex. 2006;16(9):1283-8. doi: 10.1093/cercor/bhj070
13. Moossavi A, Mohsen S. Noninvasive neuromodulation of tinnitus with transcranial current stimulation techniques with insight into neurobiology and neuroimaging. Aud Vestib Res. 2016;25(2):89-97.
14. Fregni F, Marcondes R, Boggio PS, Marcolin MA, Rigonatti SP, Sanchez TG, et al. Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Eur J Neurol. 2006;13(9):996-1001. doi: 10.1111/j.1468-1331.2006.01414.x
15. Bodner M, Kroger J, Fuster JM. Auditory memory cells in dorsolateral prefrontal cortex. Neuroreport. 996;7(12):1905-8. doi: 10.1097/00001756-199608120-00006
16. Bastos S, Ganz Sanchez T. Effects of transcranial techniques of neuromodulation on tinnitus perception and distress: a systematic review. J Hear Sci. 2017;7(2):141.
17. De Ridder D, De Mulder G, Walsh V, Muggleton N, Sunaert S, Møller A. Magnetic and electrical stimulation of the auditory cortex for intractable tinnitus. Case report. J Neurosurg. 2004;100(3):560-4. doi: 10.3171/jns.2004.100.3.0560
18. Vanneste S, Plazier M, Ost J, van der Loo E, Van de Heyning P, De Ridder D. Bilateral dorsolateral prefrontal cortex modulation for tinnitus by transcranial direct current stimulation: a preliminary clinical study. Exp Brain Res. 2010;202(4):779-85. doi: 10.1007/s00221-010-2183-9
19. Vanneste S, De Ridder D. Transcranial direct current stimulation (tDCS): a new tool for the treatment of tinnitus? In: Møller AR, Langguth B, De Ridder D, Kleinjung T, editors. Textbook of tinnitus. New York, NY: Springer Science + Business Media; 2011. p. 711-6.
20. Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2000;527 Pt 3(Pt 3):633-9. doi: 10.1111/j.1469-7793.2000.t01-1-00633.x
21. Nitsche MA, Cohen LG, Wassermann EM, Priori A, Lang N, Antal A, et al. Transcranial direct current stimulation: state of the art 2008. Brain Stimul. 2008;1(3):206-23. doi: 10.1016/j.brs.2008.06.004
22. Miranda PC, Lomarev M, Hallett M. Modeling the current distribution during transcranial direct current stimulation. Clin Neurophysiol. 2006;117(7):1623-9. doi: 10.1016/j.clinph.2006.04.009
23. Shekhawat GS, Searchfield GD, Stinear CM. Randomized trial of transcranial direct current stimu¬lation and hearing aids for tinnitus management. Neurorehabil Neural Repair. 2014;28(5):410-9. doi: 10.1177/1545968313508655
24. Garin P, Gilain C, Van Damme JP, de Fays K, Jamart J, Ossemann M. Short-and long-lasting tinnitus relief induced by transcranial direct current stimulation. J Neurol. 2011;258(11):1940-8. doi: 10.1007/s00415-011-6037-6
25. Frank E, Schecklmann M, Landgrebe M, Burger J, Kreuzer P, Poeppl TB, et al. Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study. J Neurol. 2012;259(2):327-33. doi: 10.1007/s00415-011-6189-4
26. Faber M, Vanneste S, Fregni F, De Ridder D. Top down prefrontal affective modulation of tinnitus with multiple sessions of tDCS of dorsolateral prefrontal cortex. Brain Stimul. 2012;5(4):492-8. doi: 10.1016/j.brs.2011.09.003
27. Forogh B, Mirshaki Z, Raissi GR, Shirazi A, Mansoori K, Ahadi T. Repeated sessions of transcranial direct current stimulation for treatment of chronic subjective tinnitus: a pilot randomized controlled trial. Neurol Sci. 2016;37(2):253-9. doi: 10.1007/s10072-015-2393-9
28. Abtahi H, Okhovvat A, Heidari S, Gharagazarloo A, Mirdamadi M, Nilforoush MH, et al. Effect of transcra¬nial direct current stimulation on short-term and long-term treatment of chronic tinnitus. Am J Otolaryngol. 2018;39(2):94-6. doi: 10.1016/j.amjoto.2018.01.001
29. Cavalcanti K, Brasil-Neto JP, Allam N, Boechat-Barros R. A double-blind, placebo-controlled study of the effects of daily tDCS sessions targeting the dorsolateral prefron¬tal cortex on tinnitus handicap inventory and visual analog scale scores. Brain Stimul. 2015;8(5):978-80. doi: 10.1016/j.brs.2015.06.019
30. Pal N, Maire R, Stephan MA, Herrmann FR, Benninger DH. Transcranial direct current stimulation for the treatment of chronic tinnitus: a randomized controlled study. Brain Stimul. 2015;8(6):1101-7. doi: 10.1016/j.brs.2015.06.014
31. Gift AG. Visual analogue scales: measurement of subjective phenomena. Nurs Res. 1989;38(5):286-8.
32. Adamchic I, Langguth B, Hauptmann C, Tass PA. Psychometric evaluation of visual analog scale for the assessment of chronic tinnitus. Am J Audiol. 2012;21(2):215-25. doi: 10.1044/1059-0889(2012/12-0010)
33. Newman CW, Jacobson GP, Spitzer JB. Development of the tinnitus handicap inventory. Arch Otolaryngol Head Neck Surg. 1996;122(2):143-8. doi: 10.1001/archotol.1996.01890140029007
34. Goebel G, Hiller W. [The tinnitus questionnaire. A standard instrument for grading the degree of tinnitus. Results of a multicenter study with the tinnitus questionnaire]. HNO. 1994;42(3):166-72. German.
35. Fackrell BY, Hoare DE. Questionnaires to measure tinnitus severity. ENT & Audiology News. 2014;22:4-6.
36. Shekhawat GS, Stinear CM, Searchfield GD. Transcranial direct current stimulation intensity and duration effects on tinnitus suppression. Neurorehabil Neural Repair. 2013;27(2):164-72. doi: 10.1177/1545968312459908
37. Joos K, De Ridder D, Van de Heyning P, Vanneste S. Polarity specific suppression effects of transcranial direct current stimulation for tinnitus. Neural Plast. 2014;2014:930860. doi: 10.1155/2014/930860
38. Figueiredo RR, de Azevedo AA, de Mello Oliveira P. Correlation analysis of the visual-analogue scale and the Tinnitus Handicap Inventory in tinnitus patients. Revista Braz J Otorhinolaryngol. 2009;75(1):76-9. doi: 10.1016/s1808-8694(15)30835-1
39. Langguth B, Salvi R, Elgoyhen AB. Emerging pharmacotherapy of tinnitus. Expert Opin Emerg Drugs. 2009;14(4):687-702. doi: 10.1517/14728210903206975
40. Campbell JP, Maxey VA, Watson WA. Hawthorne effect: implications for prehospital research. Ann Emerg Med. 1995;26(5):590-4. doi: 10.1016/s0196-0644(95)70009-9
41. Nater UM, Abbruzzese E, Krebs M, Ehlert U. Sex differences in emotional and psychophysiological responses to musical stimuli. Int J Psychophysiol. 2006;62(2):300-8. doi: 10.1016/j.ijpsycho.2006.05.011
2. Kim HJ, Lee HJ, An SY, Sim S, Park B, Kim SW, et al. Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS One. 2015;10(5):e0127578. doi: 10.1371/journal.pone.0127578
3. Emadi M, Rezaei M, Najafi S, Faramarzi A, Farahani F. Comparison of the transient evoked otoacoustic emissions (TEOAEs) and distortion products otoacoustic emissions (DPOAEs) in normal hearing subjects with and without tinnitus. Indian J Otolaryngol Head Neck Surg. 2018;70(1):115-8. doi: 10.1007/s12070-015-0824-9
4. Henry JA, Roberts LE, Caspary DM, Theodoroff SM, Salvi RJ. Underlying mechanisms of tinnitus: review and clinical implications. J Am Acad Audiol. 2014;25(1):5-22; quiz 126. doi: 10.3766/jaaa.25.1.2
5. Eggermont JJ. Pathophysiology of tinnitus. Prog Brain Res. 2007;166,19-35. doi: 10.1016/S0079-6123(07)66002-6
6. van der Loo E, Gais S, Congedo M, Vanneste S, Plazier M, Menovsky T, et al. Tinnitus intensity dependent gamma oscillations of the contralateral auditory cortex. PLoS One. 2009;4(10):e7396. doi: 10.1371/journal.pone.0007396
7. De Ridder D, Elgoyhen AB, Romo R, Langguth B. Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc Natl Acad Sci U S A. 2011;108(20):8075-80. doi: 10.1073/pnas.1018466108
8. De Ridder D, Vanneste S. EEG driven tDCS versus bifrontal tDCS for tinnitus. Front Psychiatry. 2012;3:84. doi: 10.3389/fpsyt.2012.00084
9. Schlee W, Hartmann T, Langguth B, Weisz N. Abnormal resting-state cortical coupling in chronic tinnitus. BMC Neurosci. 2009;10:11. doi: 10.1186/1471-2202-10-11
10. Langguth B, Goodey R, Azevedo A, Bjorne A, Cacace A, Crocetti A, et al. Consensus for tinnitus patient asse¬ssment and treatment outcome measurement: Tinnitus Research Initiative meeting, Regensburg, July 2006. Prog Brain Res. 2007;166:525-36. doi: 10.1016/S0079-6123(07)66050-6
11. Dobie RA. Depression and tinnitus. Otolaryngol Clin North Am. 2003;36(2):383-8. doi: 10.1016/s0030-6665(02)00168-8
12. Mühlau M, Rauschecker JP, Oestreicher E, Gaser C, Röttinger M, Wohlschläger AM, et al. Cereb Cortex. 2006;16(9):1283-8. doi: 10.1093/cercor/bhj070
13. Moossavi A, Mohsen S. Noninvasive neuromodulation of tinnitus with transcranial current stimulation techniques with insight into neurobiology and neuroimaging. Aud Vestib Res. 2016;25(2):89-97.
14. Fregni F, Marcondes R, Boggio PS, Marcolin MA, Rigonatti SP, Sanchez TG, et al. Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Eur J Neurol. 2006;13(9):996-1001. doi: 10.1111/j.1468-1331.2006.01414.x
15. Bodner M, Kroger J, Fuster JM. Auditory memory cells in dorsolateral prefrontal cortex. Neuroreport. 996;7(12):1905-8. doi: 10.1097/00001756-199608120-00006
16. Bastos S, Ganz Sanchez T. Effects of transcranial techniques of neuromodulation on tinnitus perception and distress: a systematic review. J Hear Sci. 2017;7(2):141.
17. De Ridder D, De Mulder G, Walsh V, Muggleton N, Sunaert S, Møller A. Magnetic and electrical stimulation of the auditory cortex for intractable tinnitus. Case report. J Neurosurg. 2004;100(3):560-4. doi: 10.3171/jns.2004.100.3.0560
18. Vanneste S, Plazier M, Ost J, van der Loo E, Van de Heyning P, De Ridder D. Bilateral dorsolateral prefrontal cortex modulation for tinnitus by transcranial direct current stimulation: a preliminary clinical study. Exp Brain Res. 2010;202(4):779-85. doi: 10.1007/s00221-010-2183-9
19. Vanneste S, De Ridder D. Transcranial direct current stimulation (tDCS): a new tool for the treatment of tinnitus? In: Møller AR, Langguth B, De Ridder D, Kleinjung T, editors. Textbook of tinnitus. New York, NY: Springer Science + Business Media; 2011. p. 711-6.
20. Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2000;527 Pt 3(Pt 3):633-9. doi: 10.1111/j.1469-7793.2000.t01-1-00633.x
21. Nitsche MA, Cohen LG, Wassermann EM, Priori A, Lang N, Antal A, et al. Transcranial direct current stimulation: state of the art 2008. Brain Stimul. 2008;1(3):206-23. doi: 10.1016/j.brs.2008.06.004
22. Miranda PC, Lomarev M, Hallett M. Modeling the current distribution during transcranial direct current stimulation. Clin Neurophysiol. 2006;117(7):1623-9. doi: 10.1016/j.clinph.2006.04.009
23. Shekhawat GS, Searchfield GD, Stinear CM. Randomized trial of transcranial direct current stimu¬lation and hearing aids for tinnitus management. Neurorehabil Neural Repair. 2014;28(5):410-9. doi: 10.1177/1545968313508655
24. Garin P, Gilain C, Van Damme JP, de Fays K, Jamart J, Ossemann M. Short-and long-lasting tinnitus relief induced by transcranial direct current stimulation. J Neurol. 2011;258(11):1940-8. doi: 10.1007/s00415-011-6037-6
25. Frank E, Schecklmann M, Landgrebe M, Burger J, Kreuzer P, Poeppl TB, et al. Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study. J Neurol. 2012;259(2):327-33. doi: 10.1007/s00415-011-6189-4
26. Faber M, Vanneste S, Fregni F, De Ridder D. Top down prefrontal affective modulation of tinnitus with multiple sessions of tDCS of dorsolateral prefrontal cortex. Brain Stimul. 2012;5(4):492-8. doi: 10.1016/j.brs.2011.09.003
27. Forogh B, Mirshaki Z, Raissi GR, Shirazi A, Mansoori K, Ahadi T. Repeated sessions of transcranial direct current stimulation for treatment of chronic subjective tinnitus: a pilot randomized controlled trial. Neurol Sci. 2016;37(2):253-9. doi: 10.1007/s10072-015-2393-9
28. Abtahi H, Okhovvat A, Heidari S, Gharagazarloo A, Mirdamadi M, Nilforoush MH, et al. Effect of transcra¬nial direct current stimulation on short-term and long-term treatment of chronic tinnitus. Am J Otolaryngol. 2018;39(2):94-6. doi: 10.1016/j.amjoto.2018.01.001
29. Cavalcanti K, Brasil-Neto JP, Allam N, Boechat-Barros R. A double-blind, placebo-controlled study of the effects of daily tDCS sessions targeting the dorsolateral prefron¬tal cortex on tinnitus handicap inventory and visual analog scale scores. Brain Stimul. 2015;8(5):978-80. doi: 10.1016/j.brs.2015.06.019
30. Pal N, Maire R, Stephan MA, Herrmann FR, Benninger DH. Transcranial direct current stimulation for the treatment of chronic tinnitus: a randomized controlled study. Brain Stimul. 2015;8(6):1101-7. doi: 10.1016/j.brs.2015.06.014
31. Gift AG. Visual analogue scales: measurement of subjective phenomena. Nurs Res. 1989;38(5):286-8.
32. Adamchic I, Langguth B, Hauptmann C, Tass PA. Psychometric evaluation of visual analog scale for the assessment of chronic tinnitus. Am J Audiol. 2012;21(2):215-25. doi: 10.1044/1059-0889(2012/12-0010)
33. Newman CW, Jacobson GP, Spitzer JB. Development of the tinnitus handicap inventory. Arch Otolaryngol Head Neck Surg. 1996;122(2):143-8. doi: 10.1001/archotol.1996.01890140029007
34. Goebel G, Hiller W. [The tinnitus questionnaire. A standard instrument for grading the degree of tinnitus. Results of a multicenter study with the tinnitus questionnaire]. HNO. 1994;42(3):166-72. German.
35. Fackrell BY, Hoare DE. Questionnaires to measure tinnitus severity. ENT & Audiology News. 2014;22:4-6.
36. Shekhawat GS, Stinear CM, Searchfield GD. Transcranial direct current stimulation intensity and duration effects on tinnitus suppression. Neurorehabil Neural Repair. 2013;27(2):164-72. doi: 10.1177/1545968312459908
37. Joos K, De Ridder D, Van de Heyning P, Vanneste S. Polarity specific suppression effects of transcranial direct current stimulation for tinnitus. Neural Plast. 2014;2014:930860. doi: 10.1155/2014/930860
38. Figueiredo RR, de Azevedo AA, de Mello Oliveira P. Correlation analysis of the visual-analogue scale and the Tinnitus Handicap Inventory in tinnitus patients. Revista Braz J Otorhinolaryngol. 2009;75(1):76-9. doi: 10.1016/s1808-8694(15)30835-1
39. Langguth B, Salvi R, Elgoyhen AB. Emerging pharmacotherapy of tinnitus. Expert Opin Emerg Drugs. 2009;14(4):687-702. doi: 10.1517/14728210903206975
40. Campbell JP, Maxey VA, Watson WA. Hawthorne effect: implications for prehospital research. Ann Emerg Med. 1995;26(5):590-4. doi: 10.1016/s0196-0644(95)70009-9
41. Nater UM, Abbruzzese E, Krebs M, Ehlert U. Sex differences in emotional and psychophysiological responses to musical stimuli. Int J Psychophysiol. 2006;62(2):300-8. doi: 10.1016/j.ijpsycho.2006.05.011
| Files | ||
| Issue | Vol 30 No 1 (2021) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/avr.v30i1.5305 | |
| Keywords | ||
| Transcranial direct current stimulation tinnitus neuromodulation | ||
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How to Cite
1.
Moossavi A, Najafi S. Transcranial direct current stimulation in treatment of tinnitus. Aud Vestib Res. 2020;30(1):1-8.
