Auditory evoked potential P300 characteristics in adults with and without idiopathic bilateral tinnitus
Background and Aim: Based on neurophysiological measurements, auditory and non-auditory pathways are involved in tinnitus. People who experience tinnitus may suffer from several problems such as attention disorder. The auditory evoked potential P300 is an endogenous response and depends on cognitive processes like attention. The purpose of this study was to compare the auditory P300 characteristics (amplitude and latency) in adults with and without tinnitus.
Methods: Participants were 20 adults with idiopathic bilateral tinnitus with mean duration of 8.4 ± 4.73 months, and 20 healthy adults. The P300 was recorded using oddball paradigm consisted of two standard (1000 Hz) and target stimuli (2000 Hz). To reduce eye blink during recording, all participants was instructed to look at and fixate on a dot sign located in front of them. The tinnitus handicap inventory (THI) was completed and pitch matching (PM) and loudness matching (LM) were measured in tinnitus group.
Results: P300 amplitude was lower at both Fz and Cz electrode placements in tinnitus patients compared to the normal group, but it was not statistically significant (p = 0.57). Tinnitus patients had delayed latency at Fz and Cz, but this difference was not significant either psychometric and psychoacoustic assessment had no statistically significant correlation with P300 amplitude and latency.
Conclusion: It seems that P300 characteristics are not different between adults with and without idiopathic bilateral tinnitus, may be due to using low sample size.
2. World Health Organization. International statistical classification of diseases and related health problems: Tenth revision. 2nd edition. Geneva: World Health Organization; 2004.
3. Johns LC, Hemsley D, Kuipers E. A comparison of auditory hallucinations in a psychiatric and non-psychiatric group. Br J Clin Psychol. 2002;41(Pt 1):81-6. doi: 10.1348/014466502163813
4. Coles RRA. Epidemiology of tinnitus: (2) Demographic and clinical features. J Laryngol Otol. 1984;98(S9):195-202. doi: 10.1017/S1755146300090466
5. Emadi M, Rezaei M, Najafi S, Faramarzi A, Farahani F. Comparison of the transient evoked otoacoustic emissions (TEOAEs) and distortion products otoacoustic emissions (DPOAEs) in normal hearing subjects with and without tinnitus. Indian J Otolaryngol Head Neck Surg. 2018;70(1):115-8. doi: 10.1007/s12070-015-0824-9
6. Baguley DM. Mechanisms of tinnitus. Br Med Bull. 2002;63(1):195-212. doi: 10.1093/bmb/63.1.195
7. Jastreboff PJ, Gray WC, Gold SL. Neurophysiological approach to tinnitus patients. Am J Otol. 1996;17(2):236-40.
8. De Ridder D, Elgoyhen AB, Romo R, Langguth B. Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proc Natl Acad Sci U S A. 2011;108(20):8075-80. doi: 10.1073/pnas.1018466108
9. Mohamad N, Hoare DJ, Hall DA. The consequences of tinnitus and tinnitus severity on cognition: A review of the behavioural evidence. Hear Res. 2016;332:199-209. doi: 10.1016/j.heares.2015.10.001
10. Shakarami S, Rouzbahani M, Mahdavi ME, Hosseini AF. Auditory attention and memory in normal hearing individuals with and without tinnitus. Aud Vestib Res. 2015;24(4):201-9.
11. Huang WJ, Chen WW, Zhang X. The neurophysiology of P 300--an integrated review. Eur Rev Med Pharmacol Sci. 2015;19(8):1480-8.
12. Najafi S, Rouzbahani M, Heidari F, Hosseini AF. Preliminary normative variation of auditory P300 parameters in adult individuals. Aud Vestib Res. 2017;26(2):112-6.
13. Hall JW. New handbook for auditory evoked responses. 1st ed. Boston: Pearson; 2007.
14. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9(1):97-113. doi: 10.1016/0028-3932(71)90067-4
15. Mahmoudian S, Shahmiri E, Rouzbahani M, Jafari Z, Keyhani M, Rahimi F, et al. Persian language version of the "Tinnitus Handicap Inventory": translation, standardization, validity and reliability. Int Tinnitus J. 2011;16(2):93-103.
16. Fournier P, Cuvillier AF, Gallego S, Paolino F, Paolino M, Quemar A, et al. A new method for assessing masking and residual inhibition of tinnitus. Trends Hear. 2018;22:2331216518769996. doi: 10.1177/2331216518769996
17. Attias J, Urbach D, Gold S, Shemesh Z. Auditory event related potentials in chronic tinnitus patients with noise induced hearing loss. Hear Res. 1993;71(1-2):106-13. doi: 10.1016/0378-5955(93)90026-w
18. Attias J, Furman V, Shemesh Z, Bresloff I. Impaired brain processing in noise-induced tinnitus patients as measured by auditory and visual event-related potentials. Ear Hear. 1996;17(4):327-33. doi: 10.1097/00003446-199608000-00004
19. dos Santos Filha VAV, Matas CG. Late Auditory evoked potentials in individuals with tinnitus. Braz J Otorhinolaryngol. 2010;76(2):263-70. doi: 10.1590/S1808-86942010000200019
20. Said EA. Electrophysiological differences in sensorineural hearing loss patients with and without problem-tinnitus. Egypt J Otolaryngol. 2012;28(1):22-34. doi: 10.7123/01.EJO.0000411078.05971.d1
21. Elmorsy SM, Abdeltawwab MM. Auditory P300: selective attention to 2 KHz tone-bursts in patients with idiopathic subjective tinnitus. Int J Speech Lang Pathol Audiol. 2013;30;1(1):6-11. doi: 10.12970/2311-1917.2013.01.01.2
22. Zeinun Z, Hassan MNHC, Zakaria MN, Othman NAN, Muzaimi M, Zulkafli Z. Determination of the neurocognitive status using objective measurement: p300 among tinnitus patients. International Medical Journal. 2016;23(4):391-4.
23. De Ridder D, Song J-J, Vanneste S. Frontal cortex TMS for tinnitus. Brain Stimul. 2013;6(3):355-62. doi: 10.1016/j.brs.2012.07.002.
24. Lima DO, Araújo AMGD, Branco-Barreiro FCA, Carneiro CS, Almeida LNA, Rosa MRD. Auditory attention in individuals with tinnitus. Braz J Otorhinolaryngol. 2020;86(4):461-7. doi: 10.1016/j.bjorl.2019.01.011
25. Andersson G, Eriksson J, Lundh LG, Lyttkens L. Tinnitus and cognitive interference A stroop paradigm study. J Speech Lang Hear Res. 2000;43(5):1168-73. doi: 10.1044/jslhr.4305.1168
26. Wang Y, Zhang J-N, Hu W, Li J-J, Zhou J-X, Zhang J-P, et al. The characteristics of cognitive impairment in subjective chronic tinnitus. Brain Behav. 2018;8(3):e00918. doi: 10.1002/brb3.918
27. Riga M, Papadas T, Werner JA, Dalchow CV. A clinical study of the efferent auditory system in patients with normal hearing who have acute tinnitus. Otol Neurotol. 2007;28(2):185-90. doi: 10.1097/MAO.0b013e31802e2a14
|Issue||Vol 29 No 4 (2020)|
|Tinnitus auditory evoked potential P300 attention|
|Rights and permissions|
|This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.|