The capability of gap in noise detection in patients with multiple sclerosis
Background and Aim: The temporal processing is one of the critical features in central auditory processing system; the gap in noise (GIN) test is the appropriate clinical tool for appraisal of temporal resolution which in people with multiple sclerosis may encounter with complications. Consequently, the aim of this study was to compare the results of gap in noise test in 18 to 40-year-old patients with multiple sclerosis and normal participants.
Methods: This cross-sectional non-invasive cohort study was conducted on 20 patients with relapsingremitting multiple sclerosis (mean age: 28.9 years) and 26 healthy normal hearing participant (mean age: 27.7 years) in the age range 18 to 40 years. The approximate threshold and percent of corrected responses were obtained and then were analyzed using Student’s t-test.
Results: There was an increase in gap detection and decrease in percent of corrected responses in gap in noise test within multiple sclerosis patients in comparison with normal people (p<0.0001). Moreover, there were a correlation of 78% between increasing disease duration and approximate threshold and also a correlation of 82% between increasing disease duration and corrected responses (p<0.0001).
Conclusion: Based on the findings of this study, it seems that people with multiple sclerosis suffer from some degree of disorder in the temporal resolution which might be due to involvement of central nerve system and, somehow, deficit in central auditory processing. Therefore, for evaluating the temporal resolution in people with multiple sclerosis, gap in noise test could be useful.
2. Kurnellas MP, Donahue KC, Elkabes S. Mechanisms of neuronal damage in multiple sclerosis and its animal models: role of calcium pumps and exchangers. Biochem Soc Trans. 2007;35(Pt 5):923-6.
3. Soltanzadeh A, Sharifi M, Ilkhchoui Y, Sikaroodi H. Isolated facial palsy in Iranian multiple sclerosis patients. Neurol Asia. 2008;13:73-5.
4. Lewis MS, Lilly DJ, Hutter M, Bourdette DN, Saunders J, Fausti SA. Some effects of multiple sclerosis on speech perception in noise: Preliminary findings. J Rehabil Res Dev. 2006;43(1):91-8.
5. Vleugels L, van Nunen A, Lafosse C, Ketelaer P, Vandenbussche E. Temporal and spatial resolution in foveal vision of multiple sclerosis patients. Vision Res. 1998;38(19):2987-97.
6. Rappaport JM, Gulliver JM, Phillips DP, Van Dorpe RA, Maxner CE, Bhan V. Auditory temporal resolution in multiple sclerosis. J Otolaryngol. 1994;23(5):307-24.
7. Musiek FE, Chermak GD. Handbook of (central) auditory processing disorder, Volume I: Auditory neuroscience and diagnosis. 1st ed. San Diego: Plural Publishing Inc; 2006.
8. Samelli AG, Schochat E. The gaps-in-noise test: gap detection thresholds in normal-hearing young adults. Int J Audiol. 2008;47(5):238-45.
9. Samelli AG, Schochat E. Study of the right ear advantage on gap detection tests. Braz J Otorhinolaryngol. 2008;74(2):235-40.
10. Musiek FE, Shinn JB, Jirsa R, Bamiou DE, Baran JA, Zaida E. GIN (Gaps-In-Noise) test performance in subjects with confirmed central auditory nervous system involvement. Ear Hear. 2005;26(6):608-18.
11. Sanches SG, Samelli AG, Nishiyama AK, Sanchez TG, Carvallo RM. GIN test (Gaps-in-Noise) in normal listeners with and without tinnitus. Pro Fono. 2010;22(3):257-62.
12. Mauk MD, Buonomano DV. The neural basis of temporal processing. Annu Rev Neurosci. 2004;27:307-40.
13. Guehl D, Burbaud P, Lorenzi C, Ramos C, Bioulac B, Semal C, et al. Auditory temporal processing in Parkinson's disease. Neuropsychologia. 2008;46(9):2326-35.
14. White CP, White MB, Russell CS. Invisible and visible symptoms of multiple sclerosis: which are more predictive of health distress? J Neurosci Nurs. 2008;40(2):85-95.
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