Research Article

Auditory brainstem responses in children treated with cisplatin


Background and Aim: In view of improvement in therapeutic outcome of cancer treatment in children resulting in increased survival rates and the importance of hearing in speech and language development, this research project was intended to assess the effects of cisplatin group on hearing ability in children aged 6 months to 12 years.
Methods: In this cross-sectional study, hearing of 10 children on cisplatin group medication for cancer who met the inclusion criteria was examined by recording auditory brainstem responses (ABR) using the three stimulants of click and 4 and 8 kHz tone bursts. All children were examined twice: before drug administration and within 72 hours after receiving the last dose. Then the results were compared with each other.
Results: There was a significant difference between hearing thresholds before and after drug administration (p<0.05). Right and left ear threshold comparison revealed no significant difference.
Conclusion: Ototoxic effects of cisplatin group were confirmed in this study. Insignificant difference observed in comparing right and left ear hearing thresholds could be due to small sample size. Auditory brainstem responses test especially with frequency specificity proved to be a useful method in assessing cisplatin ototoxicity.

1. Rossof AH, Slayton RE, Perlia CP. Preliminary clinical experience with cis-diamminedichloroplatinum (II) (NSC 119875, CACP). Cancer. 1972;30(6):1451-6.
2. Schaefer SD, Post JD, Close LG, Wright CG. Ototoxicity of low- and moderate-dose cisplatin. Cancer. 1985;56(8):1934-9.
3. Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V. Mechanisms of cisplatin-induced ototoxicity and prevention. Hear Res. 2007;226(1-2):157-67.
4. Truong MT, Winzelberg J, Chang KW. Recovery from cisplatin-induced ototoxicity: a case report and review. Int J Pediatr Otorhinolaryngol. 2007;71(10):1631-8.
5. Toral-Martiñón R, Shkurovich-Bialik P, Collado-Corona MA, Mora-Magaña I, Goldgrub-Listopad S, Shkurovich-Zaslavsky M. Distortion product otoacoustic emissions test is useful in children undergoing cisplatin treatment. Arch Med Res. 2003;34(3):205-8.
6. Fausti SA, Reavis KM, Helt WJ, Gordon JS, Philips DS, Konrad-Martin DL. Audiologic monitoring for ototoxicity and patient management. In: Campbell KCM, editor. Pharmacology and ototoxicity for audiologists. 1st ed. New York: Thomson-Delmar Learning; 2007. p. 231.
7. Stavroulaki P, Apostolopoulos N, Segas J, Tsakanikos M, Adamopoulos G. Evoked otoacoustic emissions--an approach for monitoring cisplatin induced ototoxicity in children. Int J Pediatr Otorhinolaryngol. 2001;59(1):47-57.
8. Hall J. New Handbook of auditory evoked responses. 1st ed. Boston: Allyn & Bacon Education; 2007.
9. Roeser RJ, Valente M, Hosford DH. Audiology diagnosis. 2nd ed. New York: Thieme Medical Publishers; 2007.
10. Stelmachowicz PG, Pittman AL, Hoover BM, Lewis DE, Moeller MP. The importance of high-frequency audibility in the speech and language development of children with hearing loss. Arch Otolaryngol Head Neck Surg. 2004;130(5):556-62.
11. Kampbell KCM. Audiologic monitoring for Ototoxicity. In: Roland PS, Rutka JA, editors. Ototoxicity. 1st ed. Hamilton: BC Decker Inc; 2004. p. 153-60.
12. Knight KR, Kraemer DF, Neuwelt EA. Ototoxicity in children receiving platinum chemotherapy: underestimating a commonly occurring toxicity that may influence academic and social development. J Clin Oncol. 2005;23(34):8588-96.
13. Katzung BG. Basic and clinical pharmacology. 8th ed. New York: McGraw-Hill; 2001.
14. Hatzopoulos S, Petruccelli J, Laurell G, Avan P, Finesso M, Martini A. Ototoxic effects of cisplatin in a Sprague-Dawley rat animal model as revealed by ABR and transiently evoked otoacoustic emission measurements. Hear Res. 2002;170(1-2):70-82.
15. Schmidt CM, Knief A, Lagosch AK, Deuster D, am Zehnhoff-Dinnesen A. Left-right asymmetry in hearing loss following cisplatin therapy in children--the left ear is slightly but significantly more affected. Ear Hear. 2008;29(6):830-7.
IssueVol 21 No 1 (2012) QRcode
SectionResearch Article(s)
Cisplatin carboplatin ototoxicity children auditory brainstem responses

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Bakhit M, Pourbakht A, Rouzbahani M, Ansari S, Kamali M. Auditory brainstem responses in children treated with cisplatin. Aud Vestib Res. 2017;21(1):46-53.