Comparison of vestibulo-ocular reflex instantaneous gain and velocity regression in differentiating the peripheral vestibular disorders
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Abstract
Background and Aim: Vestibulo-ocular reflex (VOR) gain is the central variable for estimating VOR function, and there are several algorithms to calculate gain. The current study aimed to investigate the ability of VOR instantaneous gain and velocity regression as a possible physiological biomarker for differentiating peripheral vestibular disorders of various etiologies.
Methods: Video head impulse test (vHIT) was performed on 27 healthy volunteers (normal group) and 29 patients (pathologic group) including three types of peripheral vestibulopathies including unilateral Meniere's disease, unilateral superior vestibular neuritis, and bilateral vestibulopathy.
Results: Analyses indicated that the mean VOR instantaneous gain at 40 ms, 60 ms, 80 ms, and velocity regression at 100 ms differred significantly within the normal and pathologic groups. Also, complete normative data for VOR at 40 ms, 60 ms, and 80 ms instantaneous gain has been provided for the vHIT.
Conclusion: The findings of this study suggest that different vestibular pathologies have a distinct effect on cupular-endolymph function, which could be tracked by VOR dynamic changes.
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2. MacDougall HG, Weber KP, McGarvie LA, Halmagyi GM, Curthoys IS. The video head impulse test: diagnostic accuracy in peripheral vestibulopathy. Neurology. 2009;73(14):1134-41. Neurology. 2009 Oct 6;73(14):1134-41. doi: 10.1212/WNL.0b013e3181bacf85.
3. Bartl K, Lehnen N, Kohlbecher S, Schneider E. Head Impulse Testing Using Video-oculography. Ann N Y Acad Sci. 2009;1164:331-3. doi: 10.1111/j.1749-6632.2009.03850.x.
4. Weber KP, MacDougall HG, Halmagyi GM, Curthoys IS. Impulsive testing of semicircular-canal function using video-oculography. Ann N Y Acad Sci. 2009;1164:486-91. doi: 10.1111/j.1749-6632.2008.03730.x.
5. Aw ST, Halmagyi GM, Haslwanter T, Curthoys IS, Yavor RA, Todd MJ. Three-dimensional vector analysis of the human vestibuloocular reflex in response to high-acceleration head rotations. II. Responses in subjects with unilateral vestibular loss and selective semicircular canal occlusion. J Neurophysiol. 1996;76(6):4021-30. PMID: 8985897
6. Collewijn H, Smeets JB. Early components of the human vestibulo-ocular response to head rotation: latency and gain. J Neurophysiol. 2000;84(1):376-89. PMID: 10899212
7. Lehnen N, Aw ST, Todd MJ, Halmagyi GM. Head impulse test reveals residual semicircular canal function after vestibular neurectomy. Neurology. 2004;62(12):2294-6. PMID: 15210899
8. Macdougall HG, McGarvie LA, Halmagyi GM, Curthoys IS, Weber KP. The video Head Impulse Test (vHIT) detects vertical semicircular canal dysfunction. PLoS One. 2013;8(4):e61488. doi: 10.1371/journal.pone.0061488.
9. Mantokoudis G, Tehrani AS, Wozniak A, Eibenberger K, Kattah JC, Guede CI. VOR gain by head impulse video-oculography differentiates acute vestibular neuritis from stroke. Otol Neurotol. 2015;36(3):457-65. doi: 10.1097/MAO.0000000000000638.
10. Blödow A, Pannasch S, Walther LE. Detection of isolated covert saccades with the video head impulse test in peripheral vestibular disorders. Auris Nasus Larynx. 2013;40(4):348-51. doi: 10.1016/j.anl.2012.11.002.
11. Luis L, Costa J, Muñoz E, de Carvalho M, Lehnen N, Schneider E, et al. P322: Vestibular ocular reflex dynamics with head-impulses in hereditary cerebellar ataxias. Clin Neurophysiol. 2014;125(Suppl 1):S134-S5. doi: 10.1016/s1388-2457(14)50441-5.
12. Pérez-Garrigues H, Sivera R, Vílchez JJ, Espinós C, Palau F, Sevilla T. Vestibular impairment in Charcot-Marie-Tooth disease type 4C. J Neurol Neurosurg Psychiatry. 2014;85(7):824-7. doi: 10.1136/jnnp-2013-307421.
13. Murofushi T, Kaga K. Vestibular evoked myogenic potential: its basics and clinical applications. Tokyo: Springer; 2009.
14. Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Menière's disease. American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngol Head Neck Surg. 1995;113(3):181-5. doi: 10.1016/s0194-5998(95)70102-8.
15. Schneider E, Villgrattner T, Vockeroth J, Bartl K, Kohlbecher S, Bardins S, et al. EyeSeeCam: an eye movement-driven head camera for the examination of natural visual exploration. Ann N Y Acad Sci. 2009;1164:461-7. doi: 10.1111/j.1749-6632.2009.03858.x.
16. Halmagyi GM, Curthoys IS, Cremer PD, Henderson CJ, Todd MJ, Staples MJ. The human horizontal vestibulo-ocular reflex in response to high-acceleration stimulation before and after unilateral vestibular neurectomy. Exp Brain Res. 1990;81(3):479-90. PMID: 2226683
17. Luis L, Lehnen N, Muñoz E, de Carvalho M, Schneider E, Valls-Solé J. Anticompensatory quick eye movements after head impulses: A peripheral vestibular sign in spontaneous nystagmus. J Vestib Res. 2016;25(5-6):267-71. doi: 10.3233/VES-160566.
18. Curthoys IS, MacDougall HG, McGaroie LA, Weber KP, Szmulewicz D, Manzari L, et al. The video head impulse test (vHIT). In: Jacobson GP, Shepard NT, editors. Balance function assessment and management. 2nd ed. San Diego: Plural Pub¬lishing, Inc; 2014. p. 391-430.
19. Manzari L, Burgess AM, MacDougall HG, Bradshaw AP, Curthoys IS. Rapid fluctuations in dynamic semicircular canal function in early Ménière's disease. Eur Arch Otorhinolaryngol. 2011;268(4):637-9. doi: 10.1007/s00405-010-1442-5.
20. Manzari L, MacDougall HG, Burgess AM, Curthoys IS. New, fast, clinical vestibular tests identify whether a vertigo attack is due to early Ménière's disease or vestibular neuritis. Laryngoscope. 2013;123(2):507-11. doi: 10.1002/lary.23479.
21. Luis L, Costa J, Garcia FV, Valls-Solé J, Brandt T, Schneider E, et al. Spontaneous plugging of the horizontal semicircular canal with reversible canal dysfunction and recovery of vestibular evoked myogenic potentials. Otol Neurotol. 2013;34(4):743-7. doi: 10.1097/MAO.0b013e318287f343.
22. McCaslin DL, Jacobson GP, Bennett ML, Gruenwald JM, Green AP. Predictive properties of the video head impulse test: measures of caloric symmetry and self-report dizziness handicap. Ear Hear. 2014;35(5):e185-91. doi: 10.1097/AUD.0000000000000047.
23. Schmid-Priscoveanu A, Böhmer A, Obzina H, Straumann D. Caloric and search-coil head-impulse testing in patients after vestibular neuritis. J Assoc Res Otolaryngol. 2001;2(1):72-8. PMCID: PMC3201096
24. Palla A, Straumann D. Recovery of the high-acceleration vestibulo-ocular reflex after vestibular neuritis. J Assoc Res Otolaryngol. 2004;5(4):427-35. PMCID: PMC2504572
25. Versino M, Colagiorgio P, Sacco S, Colnaghi S, Ramat S. Artifact avoidance for head impulse testing. Clin Neurophysiol. 2014;125(5):1071-3. doi: 10.1016/j.clinph.2013.09.024.
26. Black RA, Halmagyi GM, Thurtell MJ, Todd MJ, Curthoys IS. The active head-impulse test in unilateral peripheral vestibulopathy. Arch Neurol. 2005;62(2):290-3.
27. MacDougall HG, McGarvie LA, Halmagyi GM, Rogers SJ, Manzari L, Burgess AM, et al. A new saccadic indicator of peripheral vestibular function based on the video head impulse test. Neurology. 2016;87(4):410-8. doi: 10.1001/archneur.62.2.290.
2. MacDougall HG, Weber KP, McGarvie LA, Halmagyi GM, Curthoys IS. The video head impulse test: diagnostic accuracy in peripheral vestibulopathy. Neurology. 2009;73(14):1134-41. Neurology. 2009 Oct 6;73(14):1134-41. doi: 10.1212/WNL.0b013e3181bacf85.
3. Bartl K, Lehnen N, Kohlbecher S, Schneider E. Head Impulse Testing Using Video-oculography. Ann N Y Acad Sci. 2009;1164:331-3. doi: 10.1111/j.1749-6632.2009.03850.x.
4. Weber KP, MacDougall HG, Halmagyi GM, Curthoys IS. Impulsive testing of semicircular-canal function using video-oculography. Ann N Y Acad Sci. 2009;1164:486-91. doi: 10.1111/j.1749-6632.2008.03730.x.
5. Aw ST, Halmagyi GM, Haslwanter T, Curthoys IS, Yavor RA, Todd MJ. Three-dimensional vector analysis of the human vestibuloocular reflex in response to high-acceleration head rotations. II. Responses in subjects with unilateral vestibular loss and selective semicircular canal occlusion. J Neurophysiol. 1996;76(6):4021-30. PMID: 8985897
6. Collewijn H, Smeets JB. Early components of the human vestibulo-ocular response to head rotation: latency and gain. J Neurophysiol. 2000;84(1):376-89. PMID: 10899212
7. Lehnen N, Aw ST, Todd MJ, Halmagyi GM. Head impulse test reveals residual semicircular canal function after vestibular neurectomy. Neurology. 2004;62(12):2294-6. PMID: 15210899
8. Macdougall HG, McGarvie LA, Halmagyi GM, Curthoys IS, Weber KP. The video Head Impulse Test (vHIT) detects vertical semicircular canal dysfunction. PLoS One. 2013;8(4):e61488. doi: 10.1371/journal.pone.0061488.
9. Mantokoudis G, Tehrani AS, Wozniak A, Eibenberger K, Kattah JC, Guede CI. VOR gain by head impulse video-oculography differentiates acute vestibular neuritis from stroke. Otol Neurotol. 2015;36(3):457-65. doi: 10.1097/MAO.0000000000000638.
10. Blödow A, Pannasch S, Walther LE. Detection of isolated covert saccades with the video head impulse test in peripheral vestibular disorders. Auris Nasus Larynx. 2013;40(4):348-51. doi: 10.1016/j.anl.2012.11.002.
11. Luis L, Costa J, Muñoz E, de Carvalho M, Lehnen N, Schneider E, et al. P322: Vestibular ocular reflex dynamics with head-impulses in hereditary cerebellar ataxias. Clin Neurophysiol. 2014;125(Suppl 1):S134-S5. doi: 10.1016/s1388-2457(14)50441-5.
12. Pérez-Garrigues H, Sivera R, Vílchez JJ, Espinós C, Palau F, Sevilla T. Vestibular impairment in Charcot-Marie-Tooth disease type 4C. J Neurol Neurosurg Psychiatry. 2014;85(7):824-7. doi: 10.1136/jnnp-2013-307421.
13. Murofushi T, Kaga K. Vestibular evoked myogenic potential: its basics and clinical applications. Tokyo: Springer; 2009.
14. Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Menière's disease. American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngol Head Neck Surg. 1995;113(3):181-5. doi: 10.1016/s0194-5998(95)70102-8.
15. Schneider E, Villgrattner T, Vockeroth J, Bartl K, Kohlbecher S, Bardins S, et al. EyeSeeCam: an eye movement-driven head camera for the examination of natural visual exploration. Ann N Y Acad Sci. 2009;1164:461-7. doi: 10.1111/j.1749-6632.2009.03858.x.
16. Halmagyi GM, Curthoys IS, Cremer PD, Henderson CJ, Todd MJ, Staples MJ. The human horizontal vestibulo-ocular reflex in response to high-acceleration stimulation before and after unilateral vestibular neurectomy. Exp Brain Res. 1990;81(3):479-90. PMID: 2226683
17. Luis L, Lehnen N, Muñoz E, de Carvalho M, Schneider E, Valls-Solé J. Anticompensatory quick eye movements after head impulses: A peripheral vestibular sign in spontaneous nystagmus. J Vestib Res. 2016;25(5-6):267-71. doi: 10.3233/VES-160566.
18. Curthoys IS, MacDougall HG, McGaroie LA, Weber KP, Szmulewicz D, Manzari L, et al. The video head impulse test (vHIT). In: Jacobson GP, Shepard NT, editors. Balance function assessment and management. 2nd ed. San Diego: Plural Pub¬lishing, Inc; 2014. p. 391-430.
19. Manzari L, Burgess AM, MacDougall HG, Bradshaw AP, Curthoys IS. Rapid fluctuations in dynamic semicircular canal function in early Ménière's disease. Eur Arch Otorhinolaryngol. 2011;268(4):637-9. doi: 10.1007/s00405-010-1442-5.
20. Manzari L, MacDougall HG, Burgess AM, Curthoys IS. New, fast, clinical vestibular tests identify whether a vertigo attack is due to early Ménière's disease or vestibular neuritis. Laryngoscope. 2013;123(2):507-11. doi: 10.1002/lary.23479.
21. Luis L, Costa J, Garcia FV, Valls-Solé J, Brandt T, Schneider E, et al. Spontaneous plugging of the horizontal semicircular canal with reversible canal dysfunction and recovery of vestibular evoked myogenic potentials. Otol Neurotol. 2013;34(4):743-7. doi: 10.1097/MAO.0b013e318287f343.
22. McCaslin DL, Jacobson GP, Bennett ML, Gruenwald JM, Green AP. Predictive properties of the video head impulse test: measures of caloric symmetry and self-report dizziness handicap. Ear Hear. 2014;35(5):e185-91. doi: 10.1097/AUD.0000000000000047.
23. Schmid-Priscoveanu A, Böhmer A, Obzina H, Straumann D. Caloric and search-coil head-impulse testing in patients after vestibular neuritis. J Assoc Res Otolaryngol. 2001;2(1):72-8. PMCID: PMC3201096
24. Palla A, Straumann D. Recovery of the high-acceleration vestibulo-ocular reflex after vestibular neuritis. J Assoc Res Otolaryngol. 2004;5(4):427-35. PMCID: PMC2504572
25. Versino M, Colagiorgio P, Sacco S, Colnaghi S, Ramat S. Artifact avoidance for head impulse testing. Clin Neurophysiol. 2014;125(5):1071-3. doi: 10.1016/j.clinph.2013.09.024.
26. Black RA, Halmagyi GM, Thurtell MJ, Todd MJ, Curthoys IS. The active head-impulse test in unilateral peripheral vestibulopathy. Arch Neurol. 2005;62(2):290-3.
27. MacDougall HG, McGarvie LA, Halmagyi GM, Rogers SJ, Manzari L, Burgess AM, et al. A new saccadic indicator of peripheral vestibular function based on the video head impulse test. Neurology. 2016;87(4):410-8. doi: 10.1001/archneur.62.2.290.
| Files | ||
| Issue | Vol 26 No 4 (2017) | |
| Section | Research Article(s) | |
| Keywords | ||
| Vestibulo-ocular reflex vestibular neuritis Meniere's disease bilateral vestibulopathy head impulse testing | ||
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How to Cite
1.
Ahadi M, Rezazadeh N, Pourbakht A. Comparison of vestibulo-ocular reflex instantaneous gain and velocity regression in differentiating the peripheral vestibular disorders. Aud Vestib Res. 2017;26(4):195-201.
