Research Article

Effect of sex and rate of stimulus on auditory brainstem responses of children with history of preterm birth


Background and Aim: Preterm birth is one of the risk factors need comprehensive audiological assessment. In this study, the effect of sex and rate of stimulation on response of children with history of preterm birth was investigated by auditory brainstem response (ABR).
Methods: This cross-sectional study was conducted using convinience sampling. Click-evoked auditory brainstem response test with both low (21.1 c/s) and high (51.1 c/s) stimulus rates was recorded in 30 children with a history of preterm birth and 30 ones with history of term labor, as controls.
Results: Significant differences were observed in inter-peak latencies of I-III in both rates, III-V in the low rate, I-V in the high rate, and absolute latency of III wave between high and low stimulus rates (p<0.05 for all). Rate of stimulus affect on auditory brainstem response of preterm birth group was more than controls. Sex also affected on some parameters of auditory brainstem response test.
Conclusion: Preterm birth group showed longer latencies than normal group in both rates. Rate of stimulus had significant effect on results of children with history of preterm birth compared normal group. These findings may reflect the negative effect of preterm birth on neural synchronization function in response to transient stimuli.

1. Jiang ZD, Brosi DM, Wilkinson AR.Auditory neural responses to click stimuli of different rates in the brainstem of very preterm babies at term. Pediatr Res. 2002;51(4):454-9.
2. Allen MC. Neurodevelopmental outcomes of preterm infants. Curr opin Neural. 2008;21(2):123-8.
3. Woodward LJ, Moor S, Hood KM, Champion PR, Foster-cohen S, Inder TE, et al. Very preterm children show impairment across multiple neurodevelopmental domains by age 4 years. Arch Dis Child Fetal Neonatal Ed. 2009;94(5):339-44.
4. Luu TM, Ment L, Allan W, Schneider K, Vohr BR. Executive and memory function in adolecents born very preterm. Pediatrics. 2011;127(3):639-46.
5. Zhi HL, Chao C, Wikinson AR, Jiang ZD. Maximum length sequence brainstem auditory evoked response in low- risk late preterm babies. J Matern Fetal Neonatal Med. 2011;24(3):536-40.
6. Ribeiro FM, Carvallo RM. Tone-evoked ABR in full-term and preterm neonates with normal hearing. Int J Audiol. 2008;47(1):21-9.
7. Hall JW. New handbook of auditory evoked responses. 1st ed. Boston: Pearson Education Inc; 2007.
8. Burkard RF, Sims D. The human auditory brainstem response to high click rates: aging effects. Am J Audiol. 2001;10(2):53-61.
9. Amorim RB, Agostinho-presse RS, Alvarenga KF. The maturational process of the auditory system in the first year of life characterized by brainstem auditory evoked potentials. J Appl Oral sci. 2010;17:57-62.
10. Sleifer P, da Costa SS, Coser PL, Goldani MZ, Dornelles C, Weiss K. Auditory brainstem response in premature and full term children. Int J pediatr otorhinolaryngol. 2007;71(9):1449-56.
11. Li M, Zhu L, Mai X, Shao J, Lozoff B, Zhao Z. Sex and gestational age effects on auditory brainstem responses in preterm and term infants. Early Hum Dev. 2013;89(1):43-8.
12. Stuart A, Yang EY. Effect of gender on auditory brainstem response latencies and thresholds to air and bone-conducted clicks in newborns infants. J Commun Disord. 2001;34(3):229-39.
13. Casali RL, Santos MF. Auditory brainstem evoked response: response patterns of full term and premature infants. Braz J Otorhinolaryngol. 2010;76(6):729-38.
14. Thornton AR, Marotta N, Kennedy CR. The order of testing effect in otoacoustic emissions and its consequences for sex and ear differences in neonates. Hear Res. 2003;184(1-2):123-30.
15. Jiang ZD, Wu YY, Zhang L. Amplitude change with click rate in human brainstem auditory-evoked responses. Audiology. 1991;30(3):173-82.
16. Martin E, Kikinis R, Zuerrer M, Boesch C, Briner J, Kewitz G, et al. Developmental stages of human brain: an MR study. J Comput Assist Tomgor. 1988;12(9):917-22.
IssueVol 22 No 2 (2013) QRcode
SectionResearch Article(s)
Auditory brainstem response latency stimulus rate sex

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Hasani S, Jafari Z, Rouhbakhsh N, Salehi M, Panahi R. Effect of sex and rate of stimulus on auditory brainstem responses of children with history of preterm birth. Aud Vestib Res. 22(2):83-93.