Research Article

Vestibular evoked myogenic potentials in patients with inactive stage of systemic lupus erythematosus

Abstract

Background and Aim: Patients with systemic lupus erythematosus (SLE) may develop hearing and balance disorders as a result of the immune-mediated inner ear damage. Vestibular evoked myogenic potential (VEMP) is a new vestibular test assesses the vestibulospinal tract. Balance disorders such as endolymphatic hydrops may occur as a result of perisaccular deposition of immune complexes in these patients. Although the vestibular system abnormality in the patients has been demonstrated, the function of the part of vestibular system including vestibulospinal tract has not been investigated so far. This study aimed to compare the vestibular evoked myogenic potentials between patients with inactive stage of systemic lupus erythematosus and normal individuals.
Methods: In this cross-sectional study, vestibular evoked myogenic potential was recorded between 26 healthy subjects and 20 patients with lupus erythematosus in inactive stage of disease aged 20 to 50 years old, using 500 Hz-tone bursts at 95 dB nHL.
Results: Vestibular evoked myogenic potentials responses were present in all (100%) of the participants. There was no significant difference in mean peak to peak amplitude and assymetry ratio between two groups. The mean p13 and n23 latencies were significantly higher in patients (p<0.05). Duration of disease had no effect on test parameters.
Conclusion: According to the prolonged latency of vestibular evoked myogenic potentials response in patients with lupus erythematosus, lesions in the retrolabyrinthine, especially in the vestibulospinal tract is suspected. Due to small sample size, there is no possibility for generalizing this result to all patients with lupus lupus erythematosus.

1. Zeigelboim BS, Jurkiewicz AL, Palmonari A, Alberti A, Filho AR, Ferrari KA. Otoneurological evaluation in women with systemic lupus erythematosus: a preliminary study. Int. Arch. Otorhinolaryngol. 2006;10(2):126-31.
2. Karatas E, Onat AM, Durucu C, Baglam T, Kanlikama M, Altunoren O, et al. Audiovestibular disturbance in patients with systemic lupus erythematosus. Otolaryngol Head Neck Surg. 2007;136(1):82-6.
3. Maciaszczyk K, Durko T, Waszczykowska E, Erkiert-Polguj A, Pajor A. Auditory function in patients with systemic lupus erythematosus. Auris Nasus Larynx. 2011;38(1):26-32.
4. Stone JH, Francis HW. Immune-mediated inner ear disease. Current Opinion in Rheumatology. 2000;12(1):32-40.
5. Zhou G, Cox LC. Vestibular evoked myogenic potentials: history and overview. Am J Audiol. 2004;13(2):135-43.
6. Murofushi T, Shimizu K, Takegoshi H, Cheng PW. Diagnostic value of prolonged latencies in the vestibular evoked myogenic potential. Arch of Otolaryngol Head Neck Surg. 2001;127(9):1069-72.
7. Vanspauwen R, Wuyts FL, Van de Heyning PH. Improving vestibular evoked myogenic potential reliability by using a blood pressure manometer. Laryngoscope. 2006;116(1):131-5.
8. Allena M, Magis D, De Pasqua V, Schoenen J, Bisdorff AR. The vestibulo-collic reflex is abnormal in migraine. Cephalalgia. 2007;27(10):1150-5.
9. Sandhu JS, Bell S. Effects of eye position on the vestibular evoked myogenic potential. Acta oto-laryngol. 2009;129(2):175-8.
10. Hall JW. New handbook of auditory evoked responses. 1st ed. Boston: Pearson Education Inc; 2007.
11. Young YH, Huang TW, Cheng PW. Vestibular evoked myogenic potentials in delayed endolymphatic hydrops. Laryngoscope. 2002;112(9):1623-6.
12. Akkuzu G, Akkuzu B, Ozluoglu LN. Vestibular evoked myogenic potentials in benign paroxysmal positional vertigo and Meniere’s disease. Eur Arch OtoRhinoLaryngol. 2006;263(6):510-7.
13. Welgampola MS. Evoked potential testing in neuro-otology. Curr opin neurol. 2008;21(1):29-35.
14. Bruns A, Meyer O. Neuropsychiatric manifestations of systemic lupus erythematosus. Joint Bone Spine. 2006;73(6):639-45.
15. Trune DR, Craven JP, Morton JI, Mitchell C. Autoimmune disease and cochlear pathology in the C3H/lpr strain mouse. Hear Res. 1989;38(1-2):57-66.
IssueVol 22 No 2 (2013) QRcode
SectionResearch Article(s)
Keywords
Vestibular evoked myogenic potentials saccule sternocleidomastoid muscle systemic lupus erythematosus
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Farhadi R, Hajiabolhassan F, Akhlaghi M, Jalaie S, Akbarian M. Vestibular evoked myogenic potentials in patients with inactive stage of systemic lupus erythematosus. Aud Vestib Res. 2017;22(2):63-72.