Research Article

The effect of duration of multiple sclerosis and expanded disability status scale on P300

Abstract

Background and Aim: Multiple sclerosis (MS) is characterized with inflammation, demyelization and gliosis. It may be relapsing, remitting, or progressive. Cognitive impairment is relatively prevalent in patients with multiple sclerosis and as duration of disease is longer as cognition impairment is more. To understand the cognitive impairment, event related potential can be considered as a valuable tool. This study aimed to investigate the influence of duration of disease and expanded disability status scale (EDSS) on the amplitude and latency of the event related potentials of P300 in patients with multiple sclerosis.
Methods: In this cross-sectional and non-intervention study, 21 patients with multiple sclerosis with mean age of 27.8 with SD 7.1 years (between 18 to 50 years) were enrolled. The patients were selected randomly. The correlation of P300 event-related potential and oddball paradigm was assessed, using two 1000 and 2000 Hz tone burst stimulus.
Results: There was a significant correlation between the latency of P300 wave and duration of disease and expanded disability status scale (p<0.05); there was high correlation in both electrode sites (r>0.50). The correlation of amplitude of P300 and duration of disease and expanded disability status scale was not significant (p>0.05).
Conclusion: Significant correlation between the latency of P300 and the duration of multiple sclerosis and expanded disability status scale can be a sign of central nervous system changes. Besides, there is a relation between physical disability and cognitive impairments.

1. Kuhlmann T, Lingfeld G, Bitsch A, Schuchardt J. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain. 2002;125(10): 2202-12.
2. Miller JR. The importance of early diagnosis of multiple sclerosis. J Manag Care Pharm. 2004; 10(3): 4-11.
3. Kenealy SJ, Pericak Vance MA, Haines JL. The genetic epidemiology of multiple sclerosis. J Neuroimmunol. 2003;143(1-2):7-12.
4. Musiek FE, Chermak GD, Weihing J, Zappulla M, Nagle S. Diagnostic accuracy of established central auditory processing test batteries in patients with documented brain lesions. J Am Acad Audiol. 2011;22(6):342-58.
5. Hall JW. New handbook of auditory evoked responses. 1st ed. Boston: Pearson Education Inc; 2007.
6. Comi G. Electrophysiological correlates of cognitive dysfunction in multiple sclerosis. Electroencephalogr Clin Neurophysiol. 1997;103(1):53.
7. Adamaszek M, Krüger S, Dressel, A, Kessler C, Hamm A. Affective impairments in multiple sclerosis proved by event-related potentials andneuropsychology. Clin Neurophysiol. 2006;117(1):121-336.
8. Gil R, Zai L, Neau P, Jonveaux T, Agbo C, Rosolacci T, et al. Event-related auditory evoked potentials and multiple sclerosis. Electroencephalogr Clin Neurophysiol. 1993;88(3):182-7.
9. Ellger T, Bethke F, Frese A, Luettmann RJ, Buchheister A, Ringelstein EB, et al. Event-related potentials in different subtypes of multiple sclerosis-a cross-sectional study. J Neurol Sci. 2002;205(1):35-40.
10. Newton MR, Barrett G, Callanan MM. Cognitive event-related potentials in multiple sclerosis. Brain. 1989;112(6):1637-60.
11. Triantafyllou N, Voumvourakis K, Zalonis I, Sfagos K, Mantouvalos V, Malliara S, et al. Cognition in relapsing-remitting multiple sclerosis: a multichannel event-related potential (P300) study. Acta Neurol Scand. 1992;85(1):10-3.
12. Pokryszko-Dragan AP, Zagrajek M, Slotwinski K, Gruszka E, Bilinska M, Podemski R. Neuropsychological testing and event-related potentials in the assessment of cognitive performance in the patients with multiple sclerosis- a pilot study. Clin Neurol Neurosurg . 2009;111(6):503-6.
13. Margolis RH, Hunter LL. Aucoustic immitance measurments. In: Rosser RJ, Valente M, Hosford-Dunn H, editors. Audiology diagnosis. 2nd ed. New York: Thieme; 2007. p. 381-424.
14. Burkard RF,Eggermont JJ. Electric and magnetic fields of synchronous neural activity. In: Burkard RF, editor. Auditory evoked potentials. 1st ed. Baltimore: William & Wilkins; 2007. p. 2-22.
IssueVol 22 No 2 (2013) QRcode
SectionResearch Article(s)
Keywords
Multiple sclerosis event related potential tone burst stimulation expanded disability status scale
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How to Cite
1.
Rasoulifard P, Mohammadkhani G, Farahani S, Sahraiyan M, Jalaie S, Shomeil Shushtary sahar. The effect of duration of multiple sclerosis and expanded disability status scale on P300. Aud Vestib Res. 2017;22(2):56-62.