Research Article

Effects of caffeine on cervical vestibular evoked myogenic potential: a pilot study


Background and Aim: Caffeine at low doses blocks adenosine receptors. These receptors are present in all parts of the body including auditory and vestibular system. This study aimed to evaluate the effects of caffeine on cervical vestibular evoked myogenic potential (cVEMP).
Methods: In this interventional double-blind study, 40 cases (20 females and 20 males) aged 18-25 years were randomly assigned into two groups: the test group, 3 mg/kg caffeine and little sugar and dry milk in 100ml water, and the control group, placebo including sugar and dry milk in 100ml water. Myogenic potential was recorded before and after intervention with 500 Hz tone burst in 95 dBnHL.
Results: The statistical analysis revealed that there was no significant difference in p13 and n23 latency and amplitude asymmetry. However, the mean amplitudes of right ear (p=0.04) and two ears (p=0.02) of test group indicated a significant increase after caffeine ingestion. The results showed no significant difference in caffeine group compared to the placebo group in any of parameters and ears (p>0.05).
Conclusions: With current study small sample size we found no effect of 3 mg/kg dose of caffeine on cervical vestibular evoked myogenic potential. Although after intervention the significant increase in the amplitude of all samples was notable, no significant difference was found between the two groups. The present study was the first research in this area, however, larger sample size and different doses of caffeine is suggested for future studies.

1. Martin PY, Laing J, Robin Martin, Melanie Mitchell. Caffeine, cognition, and persuasion: Evidence for caffeine increasing the systematic processing of persuasive messages. J Appl Soc Psychol. 2005;35(1):160-82.
2. Ribeiro J, Sebasti A. Caffeine and Adenosine. Journal of Alzheimer’s Disease. 2010;20(Suppl 1):3-15.
3. Mfiller Ch, Scior T. Adenosine receptors and their modulators. Pharmaceutica Acta Helvetiae. 1993;68(2):77-111.
4. Vlajkovic SM, Abi S, Wang CJ, Housley GD, Thorne PR. Differential distribution of adenosine receptors in rat cochlea. Cell Tissue Res. 2007;328(3):461-71.
5. Ricci A, Norris C, Guth P. Cyclic AMP modulates sensory-neural communication at the vestibular end organ. Brain Res. 1991;565(1):78-84.
6. Bobbin RP. Caffeine and ryanodine demonstrate a role for the ryanodine receptor in the organ of Corti. Hear Res. 2002;174(1-2):172-82.
7. Soleimanian S, Farahani S, Adel Ghahraman M, Kebriaiezadeh A, Faghihzadeh S. Effects of caffeine on auditory brainstem response. Audiol. 2008;17(1):45-52. Persian.
8. Dixit A, Vaney N, Tandon OP. Effect of caffeine on central auditory pathways: an evoked potential study. Hear Res. 2006;220(1-2):61-6.
9. Pan J, Takeshita T, Morimoto K. Acute caffeine effect on repeatedly measured P300. Environ Health Prev Med. 2000;5(1):13-7.
10. Barry RJ, Johnstone SJ, Clarke AR, Rushby JA, Brown CR, McKenzie DN. Caffeine effects on ERPs and performance in an auditory Go/NoGo task. Clin Neurophysiol. 2007;118(12):2692-9.
11. Felipe L, Simões LC, Gonçalves DU, Mancini PC. Evaluation of the caffeine effect in the vestibular test. Braz J Otorhinolaryngol. 2005;71(6):758-62.
12. Enriquez A, Sklaar J, Viirre E, Chase B. Effects of caffeine on postural stability. Int Tinnitus J. 2009;15(2):161-3.
13. Litman RE, Hommer DW, Clem T, Rapaport MH, Pato CN, Pickar D. Smooth pursuit eye movements in schizophrenia: effects of neuroleptic treatment and caffeine. Psychopharmacol Bull. 1989;25(3):473-8.
14. Vanspauwen R, Wuyts FL, Van de Heyning PH. Improving vestibular evoked myogenic potential reliability by using a blood pressure manometer. Laryngoscope. 2006;116(1):131-5.
15. Lorist MM, Tops M. Caffeine, fatigue, and cognition. Brain Cogn. 2003;53(1):82-94.
16. De Carvalho M, Marcelino E, de Mendonça A. Electrophysiological studies in healthy subjects involving caffeine. J Alzheimers Dis. 2010;20(1):63-9.
17. Glade MJ. Caffeine-Not just a stimulant. Nutrition. 2010;26(10):932-8.
18. Pilli R, Naidu MUR, Pingali UR, Takallapally RKR. An electrooculographic method for the evaluation of psychotropic drugs on saccadic eye movements in healthy subjects. International Journal of Psychological Studies. 2012;4(2):75-7.
IssueVol 24 No 1 (2015) QRcode
SectionResearch Article(s)
Caffeine adenosine alutamate cervical vestibular evoked myogenic potential

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How to Cite
Tavanai E, Farahani S, Adel-Ghahraman M, Jalaie S, Kouti L, Shidfar F. Effects of caffeine on cervical vestibular evoked myogenic potential: a pilot study. Aud Vestib Res. 2015;24(1):3-10.