Research Article

Evaluation of auditory brainstem pathways in neonates with respiratory distress syndrome

Abstract

Background and Aim: Respiratory distress syndrome (RDS) is a lung disorder, which can damage the auditory brainstem pathways because of hypoxia. The aim of this study was to evaluate brainstem auditory electrophysiology changes of neonates with RDS.
Methods: fifteen term neonates who suffered from RDS, 15 term neonates admitted in the NICU for any reason except RDS, and 15 normal term neonates as control group were studied from June to November 2014. Auditory brainstem response (ABR) was recorded by clicks, delivered at 80 dBnHL, the polarity was alternative, the band pass filter and the time window were 50-2000 Hz and 15ms with total 2000 sweeps, respectively. Data were analyzed by ANOVA and paired t-test using SSPS18.
Results: The absolute latencies of waves I, III, V and I-III, I-V intervals of both ear in RDS group and the participants admitted in NICU were significantly longer than controls (p=0.00).
Conclusion: Hypoxia and asphyxia due to RDS can damage the auditory brainstem pathways in neonatal period; additionally, the neonates who were admitted in NICU are also at the risk of auditory brainstem deficit. The findings shed light on the importance of assessing the auditory brainstem function in neonates who had RDS and who were admitted in NICU.

1. Liu J, Cao HY, Wang HW, Kong XY. The role of lung ultrasound in diagnosis of respiratory distress syndrome in newborn infants. Iran J Pediatr. 2014;24(2):147-54.
2. Ong T, Striegl A, Marshall SG. The respiratory systm. In: Marcdante K, Kliegman RM, editors. Nelson essentials of pediatrics. 7th ed. Philadelphia: Elsivier Saunders; 2015. p. 455-60.
3. Saeedi R, Maemoori GA, Ayati S, Rahmani S, Gholami Robatsangi M. Comparison of neonatal complications in newborns by cesarean and vaginal delivery. Journal of Sabzevar University of Medical Sciences. 2009;16(2):108-13. Persian.
4. Jiang ZD, Brosi DM, Wilkinson AR. Brain-stem auditory function in very preterm infants with chronic lung disease: Delayed neural conduction. Clin Neurophysiol. 2006;117(7):1551-9.
5. Jiang ZD, Shao XM, Wilkinson AR. Changes in BAER amplitudes after perinatal asphyxia during the neonatal period in term infants. Brain Dev. 2006;28(9):554-9.
6. Jiang ZD, Yin R, Shao XM, Wilkinson AR. Brain-stem auditory impairment during the neonatal period in term infants after asphyxia: dynamic changes in brain-stem auditory evoked response to clicks of different rates. Clin Neurophysiol. 2004;115(7):1605-15.
7. Don M, Kwong B. Auditory brainstem response: differential diagnosis. In: Katz J, Medwetsky L, Burkard R, Hood L, editors. Handbook of clinical audiology. 6th ed. Baltimore: Lippincott Williams & Wilkins. 2009. p. 265-92.
8. Martines F, Martines E, Mucia M, Sciacca V, Salvago P. Prelingual sensorineural hearing loss and infants at risk. Int J Pediatr Otorhinolaryngol. 2013;77(4):513-8.
9. Coenraad S, Goedegebure A, van Goudoever JB, Hoeve LJ. Risk factors for auditory neuropathy spectrum disorder in NICU infants compared to normal-hearing NICU controls. Laryngoscope. 2011;121(4):852-5.
10. Jiang ZD, Brosi DM, Wilkinson AR. Differences in impaired brainstem conduction between neonatal chronic lung disease and perinatal asphyxia. Clin Neurophysiol. 2010;121(5):725-33.
11. Berg AL, Spitzer JB, Towers HM, Bartosiewicz C, Diamond BE. Newborn hearing screening in the NICU: profile of failed auditory brainstem response/passed otoacoustic emission. Pediatrics. 2005;116(4):933-8.
12. Jiang ZD, Brosi DM, Wilkinson AR. Depressed brainstem auditory electrophysiology in preterm infants after perinatal hypoxia-ischaemia. J Neurol Sci. 2009;281(1-2):28-33.
13. Strata F, deIpolyi AR, Bonham BH, Chang EF, Liu RC, Nakahara H, et al. Perinatal anoxia degrades auditory system function in rats. Proc Natl Acad Sci. 2005;102(52):19156-61.
14. Yoshikawa S, Ikeda K, Kudo T, Kobayashi T. The effects of hypoxia, premature birth, infection, ototoxic drugs, circulatory system and congenital disease on neonatal hearing loss. Auris Nasus Larynx. 2004;31(4):361-8.
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IssueVol 24 No 2 (2015) QRcode
SectionResearch Article(s)
Keywords
Neonate respiratory distress syndrome auditory brainstem response neonate intensive care unit

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How to Cite
1.
Sharifinik M, Mohammadkhani G, Veysizade M, Jalaie S. Evaluation of auditory brainstem pathways in neonates with respiratory distress syndrome. Aud Vestib Res. 2015;24(2):104-109.