Research Article

Comparison of the absolute latency of wave V in the auditory brainstem response between the children with and without Autism

Abstract

Background and Aim: Autism is a neurodevelopmental disorder characterized by disturbances in social interactions and limited and repeated behaviors. The symptoms of this disease appear before the age three. Autism affects information processing in the brain, and it also affects the relation between the nerve cells and synapses and their order. Therefore, the current study aimed at comparing the absolute latencies of wave V in the auditory brainstem response (ABR) between children with and without Autism.
Methods: A total of 15 children with Autism and 15 healthy children, aged 4 to 6 years were enrolled in the current study. ABR with click stimulus was recorded at intensity of 75 dBnHL and rate of 27.1 for both groups.
Results: The independent t-test was used in this study to determine the differences between the groups. The mean absolute latencies of ABR wave V for the right ear were 5.80 and 5.71, respectively, for the Autism and normal groups, whereas the mean absolute latencies for the left ear were 5.81 and 5.70, respectively, for the Autism and normal groups. The difference in the absolute latency of ABR wave V was significant between the groups both in the left and right ears (p<0.001).
Conclusion: Since wave V indicates the performance of the auditory system, based on the obtained results, the absolute latency of wave V can provide specialists with an appropriate prognosis for the therapeutic approaches.

1. Coutinho MB, Rocha V, Santos MC. Auditory brainstem response in two children with autism. Int J Pediatr Otorhinolaryngol. 2002;66(1):81-5. PMID: 12363427
2. DiCicco-Bloom E, Lord C, Zwaigenbaum L, Courchesne E, Dager SR, Schmitz C, et al. The developmental neurobiology of autism spectrum disorder. J Neurosci. 2006;26(26):6897-906. doi: 10.1523/jneurosci.1712-06.2006.
3. Werner E, Dawson G. Validation of the phenomenon of autistic regression using home videotapes. Arch Gen Psychiatry. 2005;62(8):889-95. doi: 10.1001/archpsyc.62.8.889.
4. Fujikawa-Brooks S, Isenberg AL, Osann K, Spence MA, Gage NM. The effect of rate stress on the auditory brainstem response in autism: a preliminary report. Int J Audiol. 2010 Feb;49(2):129-40. doi: 10.3109/14992020903289790.
5. Orekhova EV, Tsetlin MM, Butorina AV, Novikova SI, Gratchev VV, Sokolov PA, et al. Auditory cortex responses to clicks and sensory modulation difficulties in children with autism spectrum disorders (ASD). PLoS One. 2012;7(6):e39906.doi: 10.1371/journal.pone.0039906.
6. Patten E, Belardi K, Baranek GT, Watson LR, Labban JD, Oller DK. Vocal patterns in infants with autism spectrum disorder: canonical babbling status and vocalization frequency. J Autism Dev Disord. 2014;44(10):2413-28. doi: 10.1007/s10803-014-2047-4.
7. Forti S, Amadeo C, Fagnani E, Filipponi E, Pignataro L, Cesarani A, et al. Auditory brainstem responses (ABR) in normal hearing adult subjects with Down's syndrome. Brain Res. 2008;1233:58-62. doi: 10.1016/j.brainres.2008.07.078.
8. Mochizuki Y, Ohkubo H, Yoshida A, Tatara T. Auditory brain stem responses(ABR) in developmentally retarded infants and children. Brain Dev. 1986;8(3):246-56.PMID: 2429572
9. Geschwind DH, Levitt P. Autism spectrum disorders: developmental disconnection syndromes. Curr Opin Neurobiol. 2007;17(1):103-11. doi: 10.1016/j.conb.2007.01.009.
10. Roth DA, Muchnik C, Shabtai E, Hildesheimer M, Henkin Y. Evidence for atypical auditory brainstem responses in young children with suspected autism spectrum disorders. Dev Med Child Neurol. 2012;54(1):23-9.doi: 10.1111/j.1469-8749.2011.04149.x.
11. Wing L, Gould J, Gillberg C. Autism spectrum disorders in the DSM-V: better or worse than the DSM-IV? Res Dev Disabil. 2011;32(2):768-73. doi: 10.1016/j.ridd.2010.11.003.
12. Demopoulos C, Lewine JD. Audiometric profiles in autism spectrum disorders: does subclinical hearing loss impact communication? Autism Res. 2016;9(1):107-20. doi: 10.1002/aur.1495.
13. Ververi A, Vargiami E, Papadopoulou V, Tryfonas D, Zafeiriou D. Brainstem auditory evoked potentials in boys with autism: still searching for the hidden truth. Iran J Child Neurol. 2015;9(2):21-8. PMCID: PMC4515337
14. Magliaro FC, Scheuer CI, AssumpçãoJúnior FB, Matas CG. Study of auditory evoked potentials in autism. Pro Fono. 2010;22(1):31-6. PMID: 20339805
15. Miron O, Ari-Even Roth D, Gabis LV, Henkin Y, Shefer S, Dinstein I, et al. Prolonged auditory brainstem responses in infants with autism. Autism Res. 2016;9(6):689-95. doi: 10.1002/aur.1561.
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IssueVol 26 No 4 (2017) QRcode
SectionResearch Article(s)
Keywords
Autism auditory brainstem response auditory system
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How to Cite
1.
Moghadasi Boroujeni F, Akbari M, Khadivi Boroujeni MK. Comparison of the absolute latency of wave V in the auditory brainstem response between the children with and without Autism. Aud Vestib Res. 2017;26(4):209-214.