Temporal Processing Abilities in Children with Repaired Cleft Lip and Palate- A Systematic Review
Abstract
Background and Aim: Children with repaired cleft lip and palate (RCLP) are at increased risk for auditory processing difficulties, particularly in speech perception in noise and temporal auditory processing. Although emerging evidence suggests deficits in central auditory processing in this population, a systematic synthesis of temporal processing abilities remains limited. This review aimed to critically evaluate and synthesize existing evidence on temporal auditory processing abilities in children with RCLP.
Recent Findings: A systematic literature search was conducted independently by two reviewers across PubMed, Scopus, CINAHL, ScienceDirect, and ProQuest for studies published between January 2000 and March 2025. Study selection was performed through title, abstract, and full-text screening. Eligibility criteria were defined using the PICOS framework, and risk of bias was assessed for all included studies. Of 1,132 identified records, 12 studies met the inclusion criteria. The reviewed evidence consistently demonstrated auditory processing deficits in children with RCLP, with temporal processing identified as the most frequently and severely affected domain. Across studies, children with RCLP showed significantly poorer temporal processing performance compared to craniofacially typical peers.
Conclusion: This review underscores the clinical relevance of temporal auditory processing deficits in children with repaired cleft lip and palate. Unrecognized temporal processing impairments may adversely affect academic performance, reading skills, and speech–language development. Incorporating temporal auditory processing assessment into routine audiological evaluations is therefore recommended for early identification and targeted intervention. Future research should further investigate other subtypes of auditory processing disorders in this population to enhance clinical management strategies.
2. Stanier P, Moore GE. Genetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts. Hum Mol Genet. 2004;13 Spec No 1:R73-81. [DOI:10.1093/hmg/ddh052]
3. Nopoulos P, Berg S, Canady J, Richman L, Van Demark D, Andreasen NC. Abnormal brain morphology in patients with isolated cleft lip, cleft palate, or both: a preliminary analysis. Cleft Palate Craniofac J. 2000;37(5):441-6. [DOI:10.1597/1545-1569_2000_037_0441_abmipw_2.0.co_2]
4. Yang FF, McPherson B, Shu H, Xie N, Xiang K. Structural abnormalities of the central auditory pathway in infants with nonsyndromic cleft lip and/or palate. Cleft Palate Craniofac J. 2012;49(2):137-45. [DOI:10.1597/11-014]
5. Roberts JE, Rosenfeld RM, Zeisel SA. Otitis media and speech and language: a meta-analysis of prospective studies. Pediatrics. 2004;113(3 Pt 1):e238-48. [DOI:10.1542/peds.113.3.e238]
6. Fortenbaugh FC, DeGutis J, Esterman M. Recent theoretical, neural, and clinical advances in sustained attention research. Ann N Y Acad Sci. 2017;1396(1):70-91. [DOI:10.1111/nyas.13318]
7. Jain C, Tanniru K, Kalarikkal G. Performance of Children with and without Auditory Processing Disorders in Adaptive Temporal Gap Detection Measures. Int Arch Otorhinolaryngol. 2025;29(4):1-7. [DOI:10.1055/s-0045-1804517]
8. Musiek FE. Frequency (pitch) and duration pattern tests. J Am Acad Audiol. 1994;5(4):265-8.
9. Musiek FE, Shinn JB, Jirsa R, Bamiou DE, Baran JA, Zaida E. GIN (Gaps-In-Noise) test performance in subjects with confirmed central auditory nervous system involvement. Ear Hear. 2005;26(6):608-18. [DOI:10.1097/01.aud.0000188069.80699.41]
10. Eggermont JJ. Auditory Temporal Processing and Its Disorders. 1st ed. Oxford, UK: Oxford University Press; 2015.
11. Samelli AG, Schochat E. The gaps-in-noise test: gap detection thresholds in normal-hearing young adults. Int J Audiol. 2008;47(5):238-45. [DOI:10.1080/14992020801908244]
12. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
13. Methley AM, Campbell S, Chew-Graham C, McNally R, Cheraghi-Sohi S. PICO, PICOS and SPIDER: a comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews. BMC Health Serv Res. 2014;14:579.
14. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5(1):210. [DOI:10.1186/s13643-016-0384-4]
15. Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155(8):529-36. [DOI:10.7326/0003-4819-155-8-201110180-00009]
16. Ma X, McPherson B, Ma L. Behavioral assessment of auditory processing disorder in children with non-syndromic cleft lip and/or palate. Int J Pediatr Otorhinolaryngol. 2015;79(3):349-55. [DOI:10.1016/j.ijporl.2014.12.021]
17. Boscariol M, André KD, Feniman MR. Cleft palate children: performance in auditory processing tests. Braz J Otorhinolaryngol. 2009;75(2):213-20. [DOI:10.1016/s1808-8694(15)30780-1]
18. Zarei M, Hosseini Dastgerdi Z, Momeni A, Nouri NS. Assessment of auditory processing in children with non-syndromic cleft lip and/or palate. Hear Balance Commun. 2022;20(1):32-8. [DOI:10.1080/21695717.2021.1933317]
19. Feng Y, Lu Z. Auditory Processing Impairments Under Background Noise in Children with Non-Syndromic Cleft Lip and/or Palate. Interspeech, 2016, p. 257–61.
20. de Moraes TFD, Salvador KK, Cruz MS, Campos CF, Feniman MR. Hearing process in children with cleft lip and palate with or without history of otitis. Arquivos Internacionais de Otorrinolaringologia 2011;15:431–6.
21. Amaral MI, Martins JE, Santos MF. A study on the hearing of children with non-syndromic cleft palate/lip. Braz J Otorhinolaryngol. 2010;76(2):164-71. [DOI:10.1590/S1808-86942010000200004]
22. Laasonen M, Haapanen M-L, Mäenpää P, Pulkkinen J, Ranta R, Virsu V. Visual, auditory, and tactile temporal processing in children with oral clefts. Journal of Craniofacial Surgery 2004;15:510–8.
23. Mäenpää P, Laasonen M, Haapanen ML, Pulkkinen J, Virsu V. Crossmodal temporal processing acuity in children with oral clefts. Cleft Palate Craniofac J. 2008;45(4):393-8. [DOI:10.1597/07-050.1]
24. Laasonen M, Erkkilä AT, Isotalo E, Mäenpää PK, Pulkkinen JJ, Virsu V, et al. Serum lipid fatty acids and temporal processing acuity in children with oral clefts. Prostaglandins Leukot Essent Fatty Acids 2006;74:263–70. https://doi.org/10.1016/j.plefa.2006.01.008.
25. Maximino LP, Marcelino FC, Cavalheiro MG, Abramides DVM, Caldana ML, Corrêa CC, et al. Auditory and language skills in children with cleft lip and palate. Acta Otorrinolaringol Esp (Engl Ed). 2022;73(3):157-63.
26. B D, Jain C. Central Auditory Processing Abilities in Children with Non-Syndromic Cleft Lip/and Palate-a Behavioural Study. Indian J Otolaryngol Head Neck Surg. 2024;76(5):4146-52. [DOI:10.1007/s12070-024-04804-7]
27. Çınar FY, Polat Z. Assessment of auditory processing skills in adolescents with cleft lip and palate. Hearing Balance Commun 2023;21:262–8.
28. Sharma M, Purdy SC, Humburg P. Cluster Analyses Reveals Subgroups of Children With Suspected Auditory Processing Disorders. Front Psychol. 2019;10:2481. [DOI:10.3389/fpsyg.2019.02481]
29. Hofer-Martini S, Hofer M, Hemprich A, Berger T, Fuchs M, Meuret S. [Auditory processing in children and adolescents with cleft palate]. Laryngorhinootologie. 2021;100(1):30-37. German. [DOI:10.1055/a-1250-8639]
30. Bodoni PSB, Leoni RF, do Vale AB, da Silva PHR, Meira Junior SG, Richieri Costa A (in memorian), et al. Neuropsychological functioning and its relationship with brain anatomical measures of children and adolescents with non-syndromic cleft lip and palate. Child Neuropsychol. 2021;27(1):2-16. [DOI:10.1080/09297049.2020.1776240]
31. Sándor-Bajusz KA, Dergez T, Molnár E, Hadzsiev K, Till Á, Zsigmond A, et al. Cognitive functioning and clinical characteristics of children with non-syndromic orofacial clefts: A case-control study. Front Psychol. 2023;14:1115304. [DOI:10.3389/fpsyg.2023.1115304]
32. Roberts JE, Rosenfeld RM, Zeisel SA. Otitis media and speech and language: a meta-analysis of prospective studies. Pediatrics 2004;113:e238–48.
33. Villa PC, Zanchetta S. Auditory temporal abilities in children with history of recurrent otitis media in the first years of life and persistent in preschool and school ages. Codas. 2014;26(6):494-502. [DOI:10.1590/2317-1782/20142014008]
| Files | ||
| Issue | Articles in Press | |
| Section | Review Article(s) | |
| Keywords | ||
| Cleft Lip Cleft Palate Auditory Perceptual Disorders Children | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |



