Research Article

Effect of acute and chronic salicylate-induced tinnitus on social disorders in animal model

Abstract

Background and aim: Many tinnitus sufferers have reported significant difficulties in social situations. Nobody knows for sure if this disability is a direct consequence of tinnitus or not. Due to the possibility of controlling longitudinal data in animal studies (pre and post tinnitus induction and its duration), this study set out to examine how acute and chronic salicylate-induced tinnitus influences on rat social interactions and aggressive behaviors.
Methods: Seven rats have been assigned to the acute salicylate group and seven to the chronic salicylate group with separately sham/salin peers (n=7) for each of them to examine the effects of duration of salicylate-induced tinnitus on social behaviors. Rats has been evaluated using the following measures: auditory brainstem response (ABR), pre-pulse inhibition (PPI), gap pre-pulse inhibition of acoustic startle (GPIAS), social interaction and aggressive behaviors tests. These assessments were conducted at baseline, 6 hours post salicylate injection in acute group and one day after salicylate injection in chronic group (400mg/kg, per day).
Results: GPIAS test was significantly decreased after acute and chronic salicylate injection, which confirmed the induction of tinnitus. Some social contact and aggressive behaviors after salicylate injection were significantly different in both acute and chronic groups. However, other social interactions and aggressive behaviors were significantly increased only after chronic salicylate injections.
Conclusions: According to the findings, salicylate induced tinnitus may have an effect on social behavior and aggression. Rats' aggressive behavior increased following chronic tinnitus induction, suggesting that the duration of tinnitus has an effect.

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Keywords
Tinnitus salicylate pre-pulse inhibition social interaction test aggressive behavior
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Rezapour M, Farrahizadeh M, Akbari M. Effect of acute and chronic salicylate-induced tinnitus on social disorders in animal model. Aud Vestib Res. 2024;.