Effects of Rh-Negative Blood Group on Pure Tone Thresholds and Immittance Test Results
-
Kamalakannan Karupaiah
,
Sundaresan Ramachandran
,
Delna Saji
,
Jerlin Xavier
,
Ann Rose Rose Chiyezhan
,
Nilesh Jeevandas Washnik
,
Prashanth Prabhu
Abstract
Background and Aim: Human blood group system variations may impact the individual's health and hearing status. It was found that individuals with O-positive blood are more prone to noise-induced hearing loss, and they exhibit reduced amplitude in otoacoustic emissions, elevated Acoustic Reflex Threshold (ART), and a slightly higher resonance frequency of the middle ear. Hence, a study was needed to observe if the same trend is followed for those with Rh-ve blood groups.
Methods: A cross-sectional group post-test-only design with a non-random convenient sample was applied. This study was conducted with forty adult female participants with a pure tone threshold range of less than or equal to 15 dBHL and ages ranging from 18 to 25 years. In each blood group (A–, B–, O–, AB–), 10 participants were recruited. All participants underwent immittance evaluation, pure tone audiometry, and extended high-frequency audiometry.
Results: On analyzing the data, participants with the O negative blood group showed significantly elevated ART in both ipsilateral and contralateral ears. Also, there was no significant difference for pure tone thresholds for the frequencies 250 Hz to 16 kHz and tympanometry findings.
Conclusion: This study indicates that the elevated ARTs in O negative blood group people could be attributed to relatively increased stiffness in the middle ear and fewer outer hair cells compared with other blood groups.
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21. Sarve AR, Megha K, Hem D. Does Hearing Thresholds Vary Across Different Blood Groups? J Health Allied Sci. 2019;9(1):17-21. [DOI:10.1055/s-0039-1692034]
22. Kemp DT. Otoacoustic emissions, their origin in cochlear function, and use. Br Med Bull. 2002;63:223-41. [DOI:10.1093/bmb/63.1.223]
23. Lonsbury-Martin BL, Martin GK. Distortion-Product Otoacoustic Emissions in Populations with Normal Hearing Sensitivity. In: Robinette MS, Glattke TJ, editors. Otoacoustic Emissions: clinical Applications. 3rd ed. New York: Thieme; 2007. p. 107-30.
24. Takayama W, Endo A, Koguchi H, Sugimoto M, Murata K, Otomo Y. The impact of blood type O on mortality of severe trauma patients: a retrospective observational study. Crit Care. 2018;22(1):100. [DOI:10.1186/s13054-018-2022-0]
25. Salt AN, Melichar I, Thalmann R. Mechanisms of endocochlear potential generation by stria vascularis. Laryngoscope. 1987;97(8 Pt 1):984-91. [DOI:10.1288/00005537-198708000-00020]
26. Mendus D, Sundaresan S, Grillet N, Wangsawihardja F, Leu R, Müller U, et al. Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear. Eur J Neurosci. 2014;39(8):1256-67. [DOI:10.1111/ejn.12486]
27. Koster T, Blann AD, Briët E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet. 1995;345(8943):152-5. [DOI:10.1016/s0140-6736(95)90166-3]
2. Okuda H, Kajii E. The evolution and formation of RH genes. Leg Med (Tokyo). 2002;4(3):139-55. [DOI:10.1016/s1344-6223(02)00031-7]
3. Anstee DJ. The relationship between blood groups and disease. Blood. 2010;115(23):4635-43. [DOI:10.1182/blood-2010-01-261859]
4. Rana R, Ranjan V, Kumar N. Association of ABO and Rh Blood Group in Susceptibility, Severity, and Mortality of Coronavirus Disease 2019: A Hospital-Based Study From Delhi, India. Front Cell Infect Microbiol. 2021;11. [DOI:10.3389/fcimb.2021.767771]
5. Remezal M, Gil-Loyzaga P, Oriol R. Ultrastructural localization of H human-blood-group immunoreactivity rat cochlear hair cells. ORL J Otorhinolaryngol Relat Spec. 1993;55(4):205-7. [DOI:10.1159/000276423]
6. Chow KT, McPherson B, Fuente A. Otoacoustic emissions in young adults: Effects of blood group. Hear Res. 2016;333:194-200. [DOI:10.1016/j.heares.2015.09.006]
7. Chen WW, Chow KT, McPherson B. ABO Blood Group and Cochlear Status: Otoacoustic Emission Markers. Ear Hear. 2018;39(3):555-62. [DOI:10.1097/AUD.0000000000000509]
8. Prabhu P, Chandrashekhar A, Cariappa J, Ghosh N. Effect of Blood Group on Ultrahigh Frequency Auditory Sensitivity. Int Arch Otorhinolaryngol. 2018;22(4):364-7. [DOI:10.1055/s-0037-1613711]
9. Mo C, Ma TF, McPherson B. ABO blood group and cochlear function: evidence from a large sample size study. Int J Audiol. 2024;63(2):106-16. [DOI:10.1080/14992027.2022.2158379]
10. Yang Y, Hood LJ, McPherson B. Association between ABO blood group status and cochlear/neural function: auditory brainstem response findings. Acta Otolaryngol. 2021;141(3):273-8. [DOI:10.1080/00016489.2020.1858236]
11. Kamalakannan K, Sona AC, Sivaranjani S, Thiriveni S, Bhuvaneswari K, Prabhu P. Effect of Different Blood Groups on Auditory Brainstem Response Findings. Aud Vestib Res. 2023;32(4):344-50. [DOI:10.18502/avr.v32i4.13598]
12. Ayçiçek A, Sargin R, Kenar F, Dereköy FS. Can Rh antigens be a risk factor in noise-induced hearing loss? Eur Arch Otorhinolaryngol. 2009;266(3):363-6. [DOI:10.1007/s00405-008-0753-2]
13. Sequi-Canet JM, Sequi-Sabater JM, Collar-Castillo JI, Orta-Sibu N. Are ABO Blood Groups or Rh Antigen Perinatal Factors Affecting the Pass Rate of Transient Otoacoustic Emissions Screening Tests in Healthy Newborns during the First 48 h of Life? Int J Neonatal Screen. 2019;5(1):4. [DOI:10.3390/ijns5010004]
14. Doğru H, Tüz M, Uygur K. Correlation between blood group and noise-induced hearing loss. Acta Otolaryngol. 2003;123(8):941-2. [DOI:10.1080/00016480310000746]
15. Clarck JL, Roesser RJ, Mendryagal M. Middle ear measures. In: Roesser RJ, Valente M, Hosford-Dunn H, editors. Audiology diagnosis, 2nd ed. New York: Thieme Medical Publisher; 2011. p. 380-39.
16. Prabhu P, Shaji SR, Vipinan KM, Ramanunny NV, Nagaraju B. Effect of different blood groups on tympanometric findings and acoustic reflex thresholds. Eur Arch Otorhinolaryngol. 2020;277(12):3513-8. [DOI:10.1007/s00405-020-06244-9]
17. Bider-Canfield Z, Cotterchio M. Self-reported ABO blood type compared with DNA-derived blood group. Epidemiology. 2014;25(6):936-7. [DOI:10.1097/EDE.0000000000000156]
18. American National Standards Institute. Maximum permissible ambient noise for audiometric test rooms (ANSI S3.1-1999). New York: American National Standards Institute; 1999.
19. Carhart R, Jerger JF. Preferred Method For Clinical Determination Of Pure-Tone Thresholds. Journal of speech and hearing disorders. 1959:24(4), 330-45. [DOI:10.1044/jshd.2404.330]
20. Schairer KS, Feeney MP, Sanford CA. Acoustic reflex measurement. Ear Hear. 2013;34 Suppl 1: 43S-7S. [DOI:10.1097/AUD.0b013e31829c70d9]
21. Sarve AR, Megha K, Hem D. Does Hearing Thresholds Vary Across Different Blood Groups? J Health Allied Sci. 2019;9(1):17-21. [DOI:10.1055/s-0039-1692034]
22. Kemp DT. Otoacoustic emissions, their origin in cochlear function, and use. Br Med Bull. 2002;63:223-41. [DOI:10.1093/bmb/63.1.223]
23. Lonsbury-Martin BL, Martin GK. Distortion-Product Otoacoustic Emissions in Populations with Normal Hearing Sensitivity. In: Robinette MS, Glattke TJ, editors. Otoacoustic Emissions: clinical Applications. 3rd ed. New York: Thieme; 2007. p. 107-30.
24. Takayama W, Endo A, Koguchi H, Sugimoto M, Murata K, Otomo Y. The impact of blood type O on mortality of severe trauma patients: a retrospective observational study. Crit Care. 2018;22(1):100. [DOI:10.1186/s13054-018-2022-0]
25. Salt AN, Melichar I, Thalmann R. Mechanisms of endocochlear potential generation by stria vascularis. Laryngoscope. 1987;97(8 Pt 1):984-91. [DOI:10.1288/00005537-198708000-00020]
26. Mendus D, Sundaresan S, Grillet N, Wangsawihardja F, Leu R, Müller U, et al. Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear. Eur J Neurosci. 2014;39(8):1256-67. [DOI:10.1111/ejn.12486]
27. Koster T, Blann AD, Briët E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet. 1995;345(8943):152-5. [DOI:10.1016/s0140-6736(95)90166-3]
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How to Cite
1.
Karupaiah K, Ramachandran S, Saji D, Xavier J, Chiyezhan AR, Washnik NJ, Prabhu P. Effects of Rh-Negative Blood Group on Pure Tone Thresholds and Immittance Test Results. Aud Vestib Res. 2024;.
