Repetitive transcranial magnetic stimulation for tinnitus: influence of loudness and frequency of tinnitus on tinnitus suppression
-
Maryam Emadi
,
Mohammad Rezaei
,
Farhad Farahani
,
Mohammad Haghighi
,
Mehran Shayganfar
,
Bahare Khavar Ghazalani
Abstract
Background and Aim: Tinnitus is a distressing symptom for which few treatments exist. Low-frequency repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been proposed as a treatment for chronic tinnitus. This study determined relationship between psychoacoustic parameters such as loudness and frequency of tinnitus and outcome with rTMS treatment.
Methods: Twenty six patients (22 male, 4 female) with chronic tinnitus received low frequency (1 Hz) rTMS at intensity 110% motor threshold and 1200 stimuli on three subsequent days to the left auditory cortex. The treatment outcome was assessed with loudness balance test and Tinnitus Handicap Inventory (THI).
Results: There was a significant difference between loudness of tinnitus and THI scores before and after rTMS. There was no correlation between psychoacoustic parameters loudness and frequency of tinnitus and rTMS treatment outcome.
Conclusion: Our data suggest that repetitive transcranial magnetic stimulation, regardless of loudness and frequency of tinnitus, can be used as a therapeutical tool for the treatment of tinnitus.
1. Heller AJ. Classification and epidemiology of tinnitus. Otolaryngol Clin North Am. 2003;36(2):239-48.
2. Dobie RA. Depression and tinnitus. Otolaryngol Clin North Am. 2003;36(2):383-8.
3. Vio MM, Holme RH. Hearing loss and tinnitus: 250 million people and a US$10 billion potential market. Drug Discov Today. 2005;10(19):1263-5.
4. Dobie RA. A review of randomized clinical trials in tin¬nitus. Laryngoscope. 1999;109(8):1202-11.
5. Giraud AL, Chéry-Croze S, Fischer G, Fischer C, Vighetto A, Grégoire MC, et al. A selective imaging of tinnitus. Neuroreport. 1999;10(1):1-5.
6. Moossavi A, Mohsen S. Noninvasive neuromodulation of tinnitus with transcranial current stimulation techniques with insight into neurobiology and neuroimaging. Aud Vest Res. 2016;25(2): 89-97.
7. Aazh H, Moore BCJ. A comparison between tinnitus retraining therapy and a simplified version in treatment of tinnitus in adults. Aud Vest Res. 2016;25(1):14-23.
8. Emadi M, Rezaei M, Najafi S, Faramarzi A, Farahani F. Comparison of the transient evoked otoacoustic emissions (TEOAEs) and distortion products otoacoustic emissions (DPOAEs) in normal hearing subjects with and without tinnitus. Otolaryngol Head Neck Surg. 2015. doi:10.1007/s12070-015-0824-9
9. Tonndorf J. The analogy between tinnitus and pain: a suggestion for a physiological basis of chronic tinnitus. Hear Res. 1987;28(2-3):271-5.
10. Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N, et al. Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature. 1995;375(6531):482-4.
11. Mühlnickel W, Elbert T, Taub E, Flor H. Reorganization of auditory cortex in tinnitus. Proc Natl Acad Sci U S A. 1998;95(17):10340-3.
12. Gao E, Suga N. Experience-dependent corticofugal adjustment of midbrain frequency map in bat auditory system. Proc Natl Acad Sci U S A. 1998;95(21):12663-70.
13. Mirz F, Gjedde A, Ishizu K, Pedersen CB. Cortical networks subserving the perception of tinnitus--a PET study. Acta Otolaryngol Suppl. 2000;543:241-3.
14. Wang H, Tian J, Yin D, Jiang S, Yang W, Han D, et al. Regional glucose metabolic increases in left auditory cortex in tinnitus patients: a preliminary study with positron emission tomography. Chin Med J (Engl). 2001;114(8):848-51.
15. Baguley DM, Humphriss RL, Axon PR, Moffat DA. Change in tinnitus handicap after translabyrinthine vestibular schwannoma excision. Otol Neurotol. 2005;26(5):1061-3.
16. Lowry LD, Eisenman LM, Saunders JC. An absence of tinnitus. Otol Neurotol. 2004;25(4):474-8.
17. Hallett M. Transcranial magnetic stimulation and the human brain. Nature. 2000;406(6792):147-50.
18. Newman CW, Sandridge SA, Jacobson GP. Psychometric adequacy of the Tinnitus Handicap Inventory (THI) for evaluating treatment outcome. J Am Acad Audiol. 1998;9(2):153-60.
19. Theodoroff SM, Folmer RL. Repetitive transcranial magnetic stimulation as a treatment for chronic tinnitus: a critical review. Otol Neurotol. 2013;34(2):199-208.
20. Plewnia C, Reimold M, Najib A, Reischl G, Plontke SK, Gerloff C. Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: a randomised, controlled pilot study. J Neurol Neurosurg Psychiatry. 2007;78(2):152-6.
21. Minami SB, Shinden S, Okamoto Y, Watada Y, Watabe T, Oishi N, et al. Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. Auris Nasus Larynx. 2011;38(3):301-6.
22. Kleinjung T, Steffens T, Sand P, Murthum T, Hajak G, Strutz J, et al. Which tinnitus patients benefit from transcranial magnetic stimulation? Otolaryngol Head Neck Surg. 2007;137(4):589-95.
23. Khedr EM, Rothwell JC, Ahmed MA, Awad EM, Galal O. Cortical excitability and transcallosal inhibition in chronic tinnitus: transcranial magnetic study. Neurophysiol Clin. 2008;38(4):243-8.
24. Kleinjung T, Steffens T, Landgrebe M, Vielsmeier V, Frank E, Hajak G, et al. Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment. Otolaryngol Head Neck Surg. 2009;140(1):92-5.
2. Dobie RA. Depression and tinnitus. Otolaryngol Clin North Am. 2003;36(2):383-8.
3. Vio MM, Holme RH. Hearing loss and tinnitus: 250 million people and a US$10 billion potential market. Drug Discov Today. 2005;10(19):1263-5.
4. Dobie RA. A review of randomized clinical trials in tin¬nitus. Laryngoscope. 1999;109(8):1202-11.
5. Giraud AL, Chéry-Croze S, Fischer G, Fischer C, Vighetto A, Grégoire MC, et al. A selective imaging of tinnitus. Neuroreport. 1999;10(1):1-5.
6. Moossavi A, Mohsen S. Noninvasive neuromodulation of tinnitus with transcranial current stimulation techniques with insight into neurobiology and neuroimaging. Aud Vest Res. 2016;25(2): 89-97.
7. Aazh H, Moore BCJ. A comparison between tinnitus retraining therapy and a simplified version in treatment of tinnitus in adults. Aud Vest Res. 2016;25(1):14-23.
8. Emadi M, Rezaei M, Najafi S, Faramarzi A, Farahani F. Comparison of the transient evoked otoacoustic emissions (TEOAEs) and distortion products otoacoustic emissions (DPOAEs) in normal hearing subjects with and without tinnitus. Otolaryngol Head Neck Surg. 2015. doi:10.1007/s12070-015-0824-9
9. Tonndorf J. The analogy between tinnitus and pain: a suggestion for a physiological basis of chronic tinnitus. Hear Res. 1987;28(2-3):271-5.
10. Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N, et al. Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature. 1995;375(6531):482-4.
11. Mühlnickel W, Elbert T, Taub E, Flor H. Reorganization of auditory cortex in tinnitus. Proc Natl Acad Sci U S A. 1998;95(17):10340-3.
12. Gao E, Suga N. Experience-dependent corticofugal adjustment of midbrain frequency map in bat auditory system. Proc Natl Acad Sci U S A. 1998;95(21):12663-70.
13. Mirz F, Gjedde A, Ishizu K, Pedersen CB. Cortical networks subserving the perception of tinnitus--a PET study. Acta Otolaryngol Suppl. 2000;543:241-3.
14. Wang H, Tian J, Yin D, Jiang S, Yang W, Han D, et al. Regional glucose metabolic increases in left auditory cortex in tinnitus patients: a preliminary study with positron emission tomography. Chin Med J (Engl). 2001;114(8):848-51.
15. Baguley DM, Humphriss RL, Axon PR, Moffat DA. Change in tinnitus handicap after translabyrinthine vestibular schwannoma excision. Otol Neurotol. 2005;26(5):1061-3.
16. Lowry LD, Eisenman LM, Saunders JC. An absence of tinnitus. Otol Neurotol. 2004;25(4):474-8.
17. Hallett M. Transcranial magnetic stimulation and the human brain. Nature. 2000;406(6792):147-50.
18. Newman CW, Sandridge SA, Jacobson GP. Psychometric adequacy of the Tinnitus Handicap Inventory (THI) for evaluating treatment outcome. J Am Acad Audiol. 1998;9(2):153-60.
19. Theodoroff SM, Folmer RL. Repetitive transcranial magnetic stimulation as a treatment for chronic tinnitus: a critical review. Otol Neurotol. 2013;34(2):199-208.
20. Plewnia C, Reimold M, Najib A, Reischl G, Plontke SK, Gerloff C. Moderate therapeutic efficacy of positron emission tomography-navigated repetitive transcranial magnetic stimulation for chronic tinnitus: a randomised, controlled pilot study. J Neurol Neurosurg Psychiatry. 2007;78(2):152-6.
21. Minami SB, Shinden S, Okamoto Y, Watada Y, Watabe T, Oishi N, et al. Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. Auris Nasus Larynx. 2011;38(3):301-6.
22. Kleinjung T, Steffens T, Sand P, Murthum T, Hajak G, Strutz J, et al. Which tinnitus patients benefit from transcranial magnetic stimulation? Otolaryngol Head Neck Surg. 2007;137(4):589-95.
23. Khedr EM, Rothwell JC, Ahmed MA, Awad EM, Galal O. Cortical excitability and transcallosal inhibition in chronic tinnitus: transcranial magnetic study. Neurophysiol Clin. 2008;38(4):243-8.
24. Kleinjung T, Steffens T, Landgrebe M, Vielsmeier V, Frank E, Hajak G, et al. Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment. Otolaryngol Head Neck Surg. 2009;140(1):92-5.
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| Issue | Vol 25 No 3 (2016) | |
| Section | Research Article(s) | |
| Keywords | ||
| Transcranial magnetic stimulations repetitive tinnitus | ||
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How to Cite
1.
Emadi M, Rezaei M, Farahani F, Haghighi M, Shayganfar M, Khavar Ghazalani B. Repetitive transcranial magnetic stimulation for tinnitus: influence of loudness and frequency of tinnitus on tinnitus suppression. Aud Vestib Res. 2016;25(3):140-144.
