Noninvasive neuromodulation of tinnitus with transcranial current stimulation techniques with insight into neurobiology and neuroimaging

  • Abdollah Moossavi Department of Otolaryngology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • Samer Mohsen Mail Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran AND Department of Otolaryngology, School of Medicine, Damascus University, Damascus, Syria
Keywords:
Tinnitus, neuromodulation, transcranial direct current stimulation, transcranial random [electrical] noise stimulation, transcranial alternative current stimulation, neuroimaging

Abstract

Background and Aim: Tinnitus is an auditory phantom percept in the absence of any objective physical sound source. Although advances have been made in its treatment, there is very low percent of patients that report an elimination of their tinnitus. A novel approach using noninv­asive neuromodulation has emerged as an inter­esting and promising modality for tinnitus relief. Our aim in this review is to investigate the efficacy and the specific parameters of some types of noninvasive neuromodulation using transcranial electrical stimulation (TES) namely transcranial direct current stimulation (tDCS), transcranial alternative current stimulation (tACS), transcranial random noise stimulation (tRNS). Then we will correlate the outcomes with the findings of the most newly neurobiol­ogic and neuroimaging researches.
Recent Findings: Up to now, the optimal use of tDCS was to apply a current of 2 mA for 20 minute over both auditory cortex or dorsolateral prefrontal cortex. The results were somewhat good but still need more optimization. While there is no effects of tACS; tRNS is shown to have the more suppressive effects among the three types of TES, so it would be a promising therapeutic tool for modulating tinnitus. In addi­tion, recently many researches on tinnitus have shed light on the tinnitus generating network and it’s correlation to another functional brain networks. This article show how can the neuro­modulation be optimized by using these new concepts.
Conclusion: Although the different techniques introduced revealed promising results, further research is needed to better understand how they work and how the brain responds to neuro­modulation.

References

1. Jastreboff PJ. Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neurosci Res. 1990;8(4):221-54.
2. Baguley DM. Mechanisms of tinnitus. Br Med Bull. 2002;63:195-212.
3. Eggermont JJ, Roberts LE. The neuroscience of tinnitus. Trends Neurosci. 2004;27(11):676-82.
4. Axelsson A, Ringdahl A. Tinnitus--a study of its prevalence and characteristics. Br J Audiol. 1989;23(1):53-62.
5. Eggermont JJ. Hearing loss, hyperacusis, or tinnitus: what is modeled in animal research? Hear Res. 2013;295:140-9.
6. De Ridder D, Elgoyhen AB, Romo R, Langguth B. Phantom percepts: tinnitus and pain as persisting aversive memory networks. Proceedings of the National Academy of Sciences. Proc Natl Acad Sci U S A. 2011;108(20):8075-80.
7. Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci. 2007;27(9):2349-56.
8. De Ridder D, Fransen H, Francois O, Sunaert S, Kovacs S, Van De Heyning P. Amygdalohippocampal involvement in tinnitus and auditory memory. Acta Otolaryngol Suppl. 2006;(556):50-3.
9. Joos K, Vanneste S, De Ridder D. Disentangling depression and distress networks in the tinnitus brain. PLoS One. 2012;7(7):e40544.
10. De Ridder D, Vanneste S, Freeman W. The Bayesian brain: phantom percepts resolve sensory uncertainty. Neurosci Biobehav Rev. 2014;44:4-15.
11. De Ridder D, Vanneste S. Targeting the parahippocampal area by auditory cortex stimulation in tinnitus. Brain Stimul. 2014;7(5):709-17.
12. Vanneste S, De Ridder D. Noninvasive and invasive neuromodulation for the treatment of tinnitus: an overview. Neuromodulation. 2012;15(4):350-60.
13. Miranda PC, Lomarev M, Hallett M. Modeling the current distribution during transcranial direct current stimulation. Clin Neurophysiol. 2006;117(7):1623-9.
14. Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2000;527 Pt 3:633-9.
15. Nitsche MA, Nitsche MS, Klein CC, Tergau F, Rothwell JC, Paulus W. Level of action of cathodal DC polarisation induced inhibition of the human motor cortex. Clin Neurophysiol. 2003;114(4):600-4.
16. Zaghi S, de Freitas Rezende L, de Oliveira LM, El-Nazer R, Menning S, Tadini L, et al. Inhibition of motor cortex excitability with 15Hz transcranial alternating current stimulation (tACS). Neurosci Lett. 2010;479(3):211-4.
17. Zaehle T, Rach S, Herrmann CS. Transcranial alternating current stimulation enhances individual alpha activity in human EEG. PLoS One. 2010;5(11):e13766.
18. Datta A, Dmochowski JP, Guleyupoglu B, Bikson M, Fregni F. Cranial electrotherapy stimulation and transcranial pulsed current stimulation: a computer based high-resolution modeling study. Neuroimage. 2013;65:280-7.
19. Terney D, Chaieb L, Moliadze V, Antal A, Paulus W. Increasing human brain excitability by transcranial high-frequency random noise stimulation. J Neurosci. 2008;28(52):14147-55.
20. Nitsche MA, Boggio PS, Fregni F, Pascual-Leone A. Treatment of depression with transcranial direct current stimulation (tDCS): a review. Exp Neurol. 2009;219(1):14-9.
21. Fertonani A, Pirulli C, Miniussi C. Random noise stimulation improves neuroplasticity in perceptual learning. J Neurosci. 2011;31(43):15416-23.
22. Fregni F, Marcondes R, Boggio PS, Marcolin MA, Rigonatti SP, Sanchez TG, et al. Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Eur J Neurol. 2006;13(9):996-1001.
23. Schlee W, Weisz N, Bertrand O, Hartmann T, Elbert T. Using auditory steady state responses to outline the functional connectivity in the tinnitus brain. PLoS One. 2008;3(11):e3720.
24. Vanneste S, Plazier M, Ost J, van der Loo E, Van de Heyning P, De Ridder D. Bilateral dorsolateral prefrontal cortex modulation for tinnitus by transcranial direct current stimulation: a preliminary clinical study. Exp Brain Res. 2010;202(4):779-85.
25. Vanneste S, De Ridder D. Bifrontal transcranial direct current stimulation modulates tinnitus intensity and tinnitus-distress-related brain activity. Eur J Neurosci. 2011;34(4):605-14.
26. Faber M, Vanneste S, Fregni F, De Ridder D. Top down prefrontal affective modulation of tinnitus with multiple sessions of tDCS of dorsolateral prefrontal cortex. Brain Stimul. 2012;5(4):492-8.
27. Frank E, Schecklmann M, Landgrebe M, Burger J, Kreuzer P, Poeppl TB, et al. Treatment of chronic tinnitus with repeated sessions of prefrontal transcranial direct current stimulation: outcomes from an open-label pilot study. J Neurol. 2012;259(2):327-33.
28. Shekhawat GS, Stinear CM, Searchfield GD. Transcranial direct current stimulation intensity and duration effects on tinnitus suppression. Neurorehabil Neural Repair. 2013;27(2):164-72.
29. Shekhawat GS, Sundram F, Bikson M, Truong D, De Ridder D, Stinear CM, et al. Intensity, duration, and location of high-definition transcranial direct current stimulation for tinnitus relief. Neurorehabil Neural Repair. 2016;30(4):349-59.
30. Vanneste S, Fregni F, De Ridder D. Head-to-head comparison of transcranial random noise stimulation, transcranial AC stimulation, and transcranial DC stimulation for tinnitus. Front Psychiatry. 2013;4:158.
31. Claes L, Stamberger H, Van de Heyning P, De Ridder D, Vanneste S. Auditory cortex tACS and tRNS for tinnitus: single versus multiple sessions. Neural Plast. 2014;2014:436713.
32. Joos K, De Ridder D, Vanneste S. The differential effect of low- versus high-frequency random noise stimulation in the treatment of tinnitus. Exp Brain Res. 2015;233(5):1433-40.
33. Smit JV, Janssen ML, Schulze H, Jahanshahi A, Van Overbeeke JJ, Temel Y, et al. Deep brain stimulation in tinnitus: current and future perspectives. Brain Res. 2015;1608:51-65.
34. Langguth B, De Ridder D. Tinnitus: therapeutic use of superficial brain stimulation. Handb Clin Neurol. 2013;116:441-67.
Published
2016-07-09
How to Cite
1.
Moossavi A, Mohsen S. Noninvasive neuromodulation of tinnitus with transcranial current stimulation techniques with insight into neurobiology and neuroimaging. Aud Vestib Res. 25(2):89-97.
Section
Review Article(s)