Tehran University of Medical Sciences Auditory and Vestibular Research 2423-480X 27 2 2018 03 07 80 85 EN Nahid Shamsi Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran Mansoureh Adel Ghahraman Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran Reza Hoseinabadi Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran Vajiheh Aghamollaii Department of Neurology, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran Shohreh Jalaie Biostatistics, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran 2017 12 31 2018 01 27 Background and Aim: Recent studies have reported connections between vestibular function and cognition and also reported more prevalence of vestibular impairment in patients with Alzheimer's disease. Because patients with amnestic mild cognitive impairment (aMCI) are more likely to develop Alzheimer's disease, this study was conducted to evaluate vestibular dysfunction of otolith organs in aMCI patients compared to normal subjects. Methods: In our case-control study, 11 patients (22 ears) with aMCI with mean age of 56.73±8.83 years and 11 normal participants (22 ears) with mean age of 54.30±7.4 years were eva­luated for ocular and cervical vestibular evoked myogenic potentials (o- and cVEMP). Occurrence of VEMP responses, amplitude, latency and threshold of these waves were recorded and compared between the two groups. Results: Ocular VEMP was absent in 63.6% of aMCI patients and in 18.2% of the normal group. The difference was significant (p=0.002), while occurrence rate, amplitude, latencies and threshold of cVEMP were not significantly different between the two groups (p>0.05). McNemar's test showed that there was no significant relationship between occurrences of two potentials in aMCI group. Conclusion: These findings show the presence of vestibular dysfunction, especially in the pathways of ocular vestibular evoked potential, in patients with amnestic mild cognitive impairment. Given that previous studies have shown that cVEMP was absent in Alzheimer's disease, absence of oVEMP can be used as an indicator for predicting future impairment in individuals with amnestic MCI. https://avr.tums.ac.ir/index.php/avr/article/view/687 https://avr.tums.ac.ir/index.php/avr/article/download/687/115