Tehran University of Medical Sciences Auditory and Vestibular Research 2423-480X 21 4 2017 07 31 19 27 Parisa Rasoulifard Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Iran Ghasem Mohammadkhani Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Iran Saeed Farahani Department of Audiology, School of Rehabilitation, Tehran University of Medical Sciences, Iran Mohammadali Sahraiyan Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Iran Shohreh Jalaie Department of Biostatistics, School of Rehabilitation, Tehran University of Medical Sciences, Iran 2017 06 17 Bachground and Aim: The involvement of central auditory nervous system is relatively prevalent in patients suffering from multiple sclerosis (MS). To understand cortex function and to investigate cognitive impairment, event related potential is considered as a valuable tool. This study was aimed to compare the amplitude and latency of the event related potentials of P300 in MS patients and normal individuals. Methods: This cross sectional study was conducted on 21 MS patients and 27 normal cases aged 18-50 years. Auditory P300 was recorded with oddball paradigm, using two tone burst stimuli (1000 and 2000). Results: In MS patients, mean latencies were significantly longer (p<0.001) and mean amplitude were significantly lower (p<0.001), in both males and females. Sex did not affect P300 latencies and amplitudes significantly. Conclusion: MS patients show some degree of event related potential abnormalities. Combination of auditory P300 and neuropsychological tests may be useful to investigate cognitive impairment in MS patients. https://avr.tums.ac.ir/index.php/avr/article/view/489